CRCGN013_HEPG2_24H:B08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tamoxifen 10.29 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

93 genes differentially expressed following the CRCGN013_HEPG2_24H:B08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ALDOC aldolase C, fructose-bisphosphate 9.76703
TRIB3 tribbles pseudokinase 3 4.85137
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 4.78159
MTERF3 mitochondrial transcription termination factor 3 4.06021
FDFT1 farnesyl-diphosphate farnesyltransferase 1 3.98224
CHMP6 charged multivesicular body protein 6 3.59973
HLA-DMA major histocompatibility complex, class II, DM alpha 3.5821
ELOVL6 ELOVL fatty acid elongase 6 3.50547
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.4192
SOAT2 sterol O-acyltransferase 2 3.37205
NSDHL NAD(P) dependent steroid dehydrogenase-like 3.3656
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.34016
SNAP25 synaptosomal-associated protein, 25kDa 3.25279
LRP10 low density lipoprotein receptor-related protein 10 3.24164
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.20503
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.14774
CDC45 cell division cycle 45 3.1347
HMOX1 heme oxygenase 1 3.05384
NOSIP nitric oxide synthase interacting protein 3.04468
IDE insulin-degrading enzyme 3.01806
DDIT4 DNA-damage-inducible transcript 4 3.01559
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 2.98241
TCTN1 tectonic family member 1 2.96349
TMEM97 transmembrane protein 97 2.95158
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.91343
E2F2 E2F transcription factor 2 2.9036
ANKRD10 ankyrin repeat domain 10 2.90014
PRKCH protein kinase C, eta 2.82504
STXBP2 syntaxin binding protein 2 2.82391
ABHD4 abhydrolase domain containing 4 2.81133
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.76499
MINDY1 MINDY lysine 48 deubiquitinase 1 2.71881
STAP2 signal transducing adaptor family member 2 2.70021
PHGDH phosphoglycerate dehydrogenase 2.66532
WASF3 WAS protein family, member 3 2.62449
CCL2 chemokine (C-C motif) ligand 2 2.61378
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.59266
MSMO1 methylsterol monooxygenase 1 2.55617
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.54401
SQSTM1 sequestosome 1 2.47364
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.45149
ECH1 enoyl CoA hydratase 1, peroxisomal 2.40022
ZNF318 zinc finger protein 318 2.32546
RRAGA Ras-related GTP binding A 2.29793
CTSL cathepsin L 2.27106
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.25512
DHCR24 24-dehydrocholesterol reductase 2.2344
SCD stearoyl-CoA desaturase (delta-9-desaturase) 2.19116
SQLE squalene epoxidase 2.18782
APP amyloid beta (A4) precursor protein 2.18162
AARS1 alanyl-tRNA synthetase 1 2.14303
IDI1 isopentenyl-diphosphate delta isomerase 1 2.13609
TREM1 triggering receptor expressed on myeloid cells 1 2.12453
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.09955
DHCR7 7-dehydrocholesterol reductase 2.09105
CALCOCO1 calcium binding and coiled-coil domain 1 2.03007
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 2.00405

decreased expression

Symbol Name Standardized Value
SLC35F2 solute carrier family 35, member F2 -5.41149
NRIP1 nuclear receptor interacting protein 1 -4.50967
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.2916
DNM1L dynamin 1-like -4.0711
TOMM34 translocase of outer mitochondrial membrane 34 -3.51497
TUBB6 tubulin, beta 6 class V -3.4175
DUSP6 dual specificity phosphatase 6 -3.38071
ZNF586 zinc finger protein 586 -3.33772
LDHD lactate dehydrogenase D -3.19701
KDM3A lysine (K)-specific demethylase 3A -3.01601
CRELD2 cysteine-rich with EGF-like domains 2 -2.99537
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.98038
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 -2.97168
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.93313
TMEM109 transmembrane protein 109 -2.75008
IER3 immediate early response 3 -2.67208
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.64203
TOR1A torsin family 1, member A (torsin A) -2.58311
CCNB2 cyclin B2 -2.55275
PLK1 polo-like kinase 1 -2.54692
CDC20 cell division cycle 20 -2.54263
CCP110 centriolar coiled coil protein 110kDa -2.50326
ZNF274 zinc finger protein 274 -2.45718
PCNA proliferating cell nuclear antigen -2.45511
TBCB tubulin folding cofactor B -2.41881
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.38338
EDN1 endothelin 1 -2.32893
CAB39 calcium binding protein 39 -2.29703
PDCD5 programmed cell death 5 -2.28714
REEP5 receptor accessory protein 5 -2.25913
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.19572
MYCBP MYC binding protein -2.14028
S100A4 S100 calcium binding protein A4 -2.10337
NVL nuclear VCP-like -2.09919
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -2.0696
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.04496