CRCGN013_HEPG2_24H:B09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tamoxifen 5.15 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

55 genes differentially expressed following the CRCGN013_HEPG2_24H:B09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ALDOC aldolase C, fructose-bisphosphate 6.55607
NOSIP nitric oxide synthase interacting protein 5.82633
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 5.17194
LCN2 lipocalin 2 4.94984
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.57339
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.07968
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.82377
GPATCH8 G patch domain containing 8 3.65107
CHN1 chimerin 1 3.52169
MTERF3 mitochondrial transcription termination factor 3 3.32112
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.14239
ABHD6 abhydrolase domain containing 6 3.11386
NSDHL NAD(P) dependent steroid dehydrogenase-like 3.03932
CYCS cytochrome c, somatic 2.78457
CARMIL1 capping protein regulator and myosin 1 linker 1 2.65374
MEF2C myocyte enhancer factor 2C 2.6053
SQOR sulfide quinone oxidoreductase 2.58971
UBQLN2 ubiquilin 2 2.52328
IL32 interleukin 32 2.40461
VRK2 vaccinia related kinase 2 2.40277
NOTCH1 notch 1 2.27837
BLVRB biliverdin reductase B 2.2746
PRR15L proline rich 15-like 2.19763
FCHO1 FCH domain only 1 2.18614
TMPRSS11E transmembrane protease, serine 11E 2.13589
TRIB3 tribbles pseudokinase 3 2.1211
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.10313
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.05606
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.0031
CEP83 centrosomal protein 83kDa 2.00262

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -9.89749
ADI1 acireductone dioxygenase 1 -6.45335
GNAS GNAS complex locus -5.33178
MAPK13 mitogen-activated protein kinase 13 -5.29034
MRPS2 mitochondrial ribosomal protein S2 -4.63584
SLC35F2 solute carrier family 35, member F2 -3.97162
GTPBP8 GTP-binding protein 8 (putative) -3.63925
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.54662
NGRN neugrin, neurite outgrowth associated -3.38079
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.25925
OXA1L oxidase (cytochrome c) assembly 1-like -3.22539
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.21369
TM9SF3 transmembrane 9 superfamily member 3 -3.08934
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.89424
LYPLA1 lysophospholipase I -2.80349
TRAPPC3 trafficking protein particle complex 3 -2.6807
TLR4 toll-like receptor 4 -2.66023
C2CD5 C2 calcium-dependent domain containing 5 -2.60737
TOR1A torsin family 1, member A (torsin A) -2.55163
ZNF586 zinc finger protein 586 -2.37828
SOCS4 suppressor of cytokine signaling 4 -2.3261
CCNB2 cyclin B2 -2.29978
TLCD3A TLC domain containing 3A -2.2068
SCAND1 SCAN domain containing 1 -2.07281
EDN1 endothelin 1 -2.0097