CRCGN013_HEPG2_24H:B10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tamoxifen 2.57 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

29 genes differentially expressed following the CRCGN013_HEPG2_24H:B10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 4.95493
CBR3 carbonyl reductase 3 4.85953
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.52718
PLSCR1 phospholipid scramblase 1 3.44607
AMDHD2 amidohydrolase domain containing 2 3.02235
HLA-DRA major histocompatibility complex, class II, DR alpha 3.01349
JADE2 jade family PHD finger 2 2.9714
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.89254
E2F2 E2F transcription factor 2 2.8903
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.81631
CIAO3 cytosolic iron-sulfur assembly component 3 2.64072
RPP38 ribonuclease P/MRP 38kDa subunit 2.5245
MAST2 microtubule associated serine/threonine kinase 2 2.32157
MAMLD1 mastermind-like domain containing 1 2.32152
C2CD2 C2 calcium-dependent domain containing 2 2.24749
LCN2 lipocalin 2 2.24373
SQOR sulfide quinone oxidoreductase 2.20647
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.10053

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -5.0
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.90782
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.71566
TWF2 twinfilin actin binding protein 2 -4.04221
ANKRD10 ankyrin repeat domain 10 -3.84941
OXA1L oxidase (cytochrome c) assembly 1-like -3.59717
CCNB2 cyclin B2 -3.32437
TSPAN4 tetraspanin 4 -2.67483
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.25184
MRPS2 mitochondrial ribosomal protein S2 -2.20504
ISOC1 isochorismatase domain containing 1 -2.05776