| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | p-nitrosodiphenylamine 20.1 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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170 genes differentially expressed following the CRCGN013_HEPG2_24H:B14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 10.0 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 7.66409 |
| LCN2 | lipocalin 2 | 7.39831 |
| PPARG | peroxisome proliferator-activated receptor gamma | 6.78551 |
| AMDHD2 | amidohydrolase domain containing 2 | 6.67982 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 6.4167 |
| INPP1 | inositol polyphosphate-1-phosphatase | 5.80949 |
| VPS28 | vacuolar protein sorting 28 homolog (S. cerevisiae) | 5.45118 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 5.30904 |
| GSTZ1 | glutathione S-transferase zeta 1 | 5.10361 |
| CHN1 | chimerin 1 | 4.90622 |
| TUBB6 | tubulin, beta 6 class V | 4.86375 |
| MVP | major vault protein | 4.81697 |
| GPER1 | G protein-coupled estrogen receptor 1 | 4.76171 |
| CDC45 | cell division cycle 45 | 4.53264 |
| ABHD4 | abhydrolase domain containing 4 | 4.50973 |
| CNPY3 | canopy FGF signaling regulator 3 | 3.82161 |
| SMAD3 | SMAD family member 3 | 3.58709 |
| ADRB2 | adrenoceptor beta 2, surface | 3.50524 |
| FOSL1 | FOS-like antigen 1 | 3.48277 |
| SKIC2 | SKI2 subunit of superkiller complex | 3.48226 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 3.35473 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 3.34667 |
| TOMM34 | translocase of outer mitochondrial membrane 34 | 3.33866 |
| SLC35F2 | solute carrier family 35, member F2 | 3.31891 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.25221 |
| UBQLN2 | ubiquilin 2 | 3.24919 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 3.21429 |
| EGR1 | early growth response 1 | 3.164 |
| GBA1 | glucosylceramidase beta 1 | 3.01407 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit | 2.99136 |
| FPGS | folylpolyglutamate synthase | 2.95814 |
| PRKCQ | protein kinase C, theta | 2.92558 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 2.89299 |
| SQSTM1 | sequestosome 1 | 2.87433 |
| IL4R | interleukin 4 receptor | 2.85509 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 2.83702 |
| GALE | UDP-galactose-4-epimerase | 2.83489 |
| SSBP2 | single-stranded DNA binding protein 2 | 2.82356 |
| TBC1D31 | TBC1 domain family, member 31 | 2.80924 |
| MAP7D1 | MAP7 domain containing 1 | 2.69804 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 2.69195 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 2.68313 |
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | 2.66495 |
| SQOR | sulfide quinone oxidoreductase | 2.66385 |
| GLRX | glutaredoxin (thioltransferase) | 2.61527 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 2.54938 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 2.54475 |
| EPAS1 | endothelial PAS domain protein 1 | 2.5121 |
| CHMP6 | charged multivesicular body protein 6 | 2.50116 |
| TMEM109 | transmembrane protein 109 | 2.48831 |
| ATP6V1E1 | ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 | 2.47086 |
| GRB10 | growth factor receptor-bound protein 10 | 2.46072 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 2.46044 |
| ANO10 | anoctamin 10 | 2.4258 |
| GPC1 | glypican 1 | 2.41116 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | 2.40232 |
| IER3 | immediate early response 3 | 2.37188 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 2.35899 |
| MTERF3 | mitochondrial transcription termination factor 3 | 2.32394 |
| MYLK | myosin light chain kinase | 2.32004 |
| IGF2R | insulin-like growth factor 2 receptor | 2.29903 |
| RALB | v-ral simian leukemia viral oncogene homolog B | 2.29691 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | 2.28587 |
| RRAGA | Ras-related GTP binding A | 2.26934 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 2.26579 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 2.24575 |
| EPHA2 | EPH receptor A2 | 2.24507 |
| LAMA5 | laminin, alpha 5 | 2.22214 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 2.20917 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 2.16118 |
| WASF3 | WAS protein family, member 3 | 2.13862 |
| BDH1 | 3-hydroxybutyrate dehydrogenase, type 1 | 2.13076 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 2.13061 |
| SOCS2 | suppressor of cytokine signaling 2 | 2.12381 |
| BLVRA | biliverdin reductase A | 2.11347 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 2.08989 |
| MED15 | mediator complex subunit 15 | 2.08903 |
| GRN | granulin | 2.08145 |
| PIGT | phosphatidylinositol glycan anchor biosynthesis, class T | 2.08114 |
| DSG2 | desmoglein 2 | 2.07842 |
| LIF | leukemia inhibitory factor | 2.07535 |
| ELAC2 | elaC ribonuclease Z 2 | 2.06994 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | 2.05724 |
| KIFBP | kinesin family binding protein | 2.04806 |
| FABP4 | fatty acid binding protein 4, adipocyte | 2.01388 |
| DFFA | DNA fragmentation factor, 45kDa, alpha polypeptide | 2.0095 |
| CIDEC | cell death-inducing DFFA-like effector c | 2.00515 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ISOC1 | isochorismatase domain containing 1 | -7.25436 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | -5.22734 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -4.84278 |
| ZW10 | zw10 kinetochore protein | -4.67599 |
| C5 | complement component 5 | -4.64136 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | -4.48637 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -4.4026 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -4.17429 |
| CDC20 | cell division cycle 20 | -4.12462 |
| STMN1 | stathmin 1 | -4.07139 |
| ADI1 | acireductone dioxygenase 1 | -3.92168 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -3.90639 |
| FGFR4 | fibroblast growth factor receptor 4 | -3.53783 |
| CETN3 | centrin, EF-hand protein, 3 | -3.45379 |
| CCNB1 | cyclin B1 | -3.38387 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | -3.31727 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -3.29195 |
| LBR | lamin B receptor | -3.28622 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -3.23426 |
| USP1 | ubiquitin specific peptidase 1 | -3.20986 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -3.15381 |
| PHGDH | phosphoglycerate dehydrogenase | -3.0224 |
| ZNF586 | zinc finger protein 586 | -2.98302 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -2.91254 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -2.86059 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -2.80647 |
| SOAT2 | sterol O-acyltransferase 2 | -2.79119 |
| MRPS2 | mitochondrial ribosomal protein S2 | -2.77077 |
| AURKB | aurora kinase B | -2.73194 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -2.72872 |
| CCNB2 | cyclin B2 | -2.72096 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | -2.68105 |
| CCNA2 | cyclin A2 | -2.66543 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -2.65628 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | -2.62084 |
| EGF | epidermal growth factor | -2.59803 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -2.58265 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.58152 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.56207 |
| PGM1 | phosphoglucomutase 1 | -2.52559 |
| LTA4H | leukotriene A4 hydrolase | -2.52241 |
| IMPACT | impact RWD domain protein | -2.509 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | -2.48787 |
| PLK1 | polo-like kinase 1 | -2.4492 |
| ENOPH1 | enolase-phosphatase 1 | -2.42429 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -2.41402 |
| EIF5 | eukaryotic translation initiation factor 5 | -2.40902 |
| PLG | plasminogen | -2.40093 |
| PYGL | phosphorylase, glycogen, liver | -2.38986 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | -2.3478 |
| ANO3 | anoctamin 3 | -2.328 |
| DDIT4 | DNA-damage-inducible transcript 4 | -2.31211 |
| GTF2A2 | general transcription factor IIA, 2, 12kDa | -2.31113 |
| CCP110 | centriolar coiled coil protein 110kDa | -2.2573 |
| NFIL3 | nuclear factor, interleukin 3 regulated | -2.23792 |
| BHMT | betaine--homocysteine S-methyltransferase | -2.23387 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -2.20154 |
| POLR1G | RNA polymerase I subunit G | -2.18798 |
| HOXA10-HOXA9 | HOXA10-HOXA9 readthrough | -2.18098 |
| MALT1 | MALT1 paracaspase | -2.16624 |
| PRPF39 | pre-mRNA processing factor 39 | -2.15832 |
| TOMM70 | translocase of outer mitochondrial membrane 70 | -2.15689 |
| ALDOC | aldolase C, fructose-bisphosphate | -2.14375 |
| LMNB1 | lamin B1 | -2.13623 |
| EHHADH | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | -2.12993 |
| PIGN | phosphatidylinositol glycan anchor biosynthesis, class N | -2.11853 |
| USP6NL | USP6 N-terminal like | -2.11007 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -2.10563 |
| VAT1 | vesicle amine transport 1 | -2.0937 |
| PLS1 | plastin 1 | -2.09288 |
| TLR4 | toll-like receptor 4 | -2.08636 |
| HPR | haptoglobin-related protein | -2.08034 |
| UBE2S | ubiquitin-conjugating enzyme E2S | -2.07542 |
| ADH6 | alcohol dehydrogenase 6 (class V) | -2.07276 |
| ACSM2A | acyl-CoA synthetase medium-chain family member 2A | -2.07117 |
| ZNF587 | zinc finger protein 587 | -2.06997 |
| DUSP6 | dual specificity phosphatase 6 | -2.06512 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -2.05765 |
| ACADSB | acyl-CoA dehydrogenase, short/branched chain | -2.05699 |
| USP48 | ubiquitin specific peptidase 48 | -2.0521 |
| IFT81 | intraflagellar transport 81 | -2.02486 |
| KNG1 | kininogen 1 | -2.01983 |
