CRCGN013_HEPG2_24H:B15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description p-nitrosodiphenylamine 10.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN013_HEPG2_24H:B15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 6.71311
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.65989
CDPF1 cysteine-rich, DPF motif domain containing 1 3.42057
CHMP6 charged multivesicular body protein 6 3.41644
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.33566
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.16158
CHN1 chimerin 1 2.9838
AMDHD2 amidohydrolase domain containing 2 2.85434
CYB561 cytochrome b561 2.77644
EVL Enah/Vasp-like 2.67946
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.59775
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.59661
INPP1 inositol polyphosphate-1-phosphatase 2.58795
LYN LYN proto-oncogene, Src family tyrosine kinase 2.50619
GADD45A growth arrest and DNA-damage-inducible, alpha 2.43762
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.39716
CNPY3 canopy FGF signaling regulator 3 2.35637
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 2.35455
PRR15L proline rich 15-like 2.26556
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.19134
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.08714
GAGE8 G antigen 8 2.02416

decreased expression

Symbol Name Standardized Value
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.04907
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.9965
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.92834
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.83054
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.73486
ADI1 acireductone dioxygenase 1 -3.11753
NRIP1 nuclear receptor interacting protein 1 -3.04203
FBXL12 F-box and leucine-rich repeat protein 12 -2.8289
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.71434
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.63972
ZNF586 zinc finger protein 586 -2.63574
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.54719
OXA1L oxidase (cytochrome c) assembly 1-like -2.48373
CCNB2 cyclin B2 -2.46101
LBR lamin B receptor -2.45232
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.38753
WASHC4 WASH complex subunit 4 -2.19526
EGF epidermal growth factor -2.18892
PCNA proliferating cell nuclear antigen -2.13921
GGCT gamma-glutamylcyclotransferase -2.07294