| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | caffeine 40.4 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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153 genes differentially expressed following the CRCGN013_HEPG2_24H:B19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 10.0 |
| CNPY3 | canopy FGF signaling regulator 3 | 8.60132 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 8.04338 |
| TXNRD1 | thioredoxin reductase 1 | 6.37587 |
| INPP1 | inositol polyphosphate-1-phosphatase | 6.17059 |
| TRIB3 | tribbles pseudokinase 3 | 5.42054 |
| EGR1 | early growth response 1 | 5.12359 |
| FOSL1 | FOS-like antigen 1 | 5.08648 |
| LCN2 | lipocalin 2 | 4.85376 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 4.28969 |
| CHN1 | chimerin 1 | 4.11977 |
| SQSTM1 | sequestosome 1 | 4.07012 |
| IER3 | immediate early response 3 | 4.02576 |
| MVP | major vault protein | 3.97851 |
| ABHD4 | abhydrolase domain containing 4 | 3.88532 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 3.69663 |
| CTSL | cathepsin L | 3.64511 |
| GPATCH8 | G patch domain containing 8 | 3.60764 |
| UBQLN2 | ubiquilin 2 | 3.52353 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 3.43273 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 3.42542 |
| RPL39L | ribosomal protein L39-like | 3.30146 |
| IL4R | interleukin 4 receptor | 3.09062 |
| SQOR | sulfide quinone oxidoreductase | 3.00614 |
| MYLK | myosin light chain kinase | 2.99423 |
| STX1A | syntaxin 1A (brain) | 2.93987 |
| VAT1 | vesicle amine transport 1 | 2.8636 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 2.83911 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | 2.83049 |
| SLC35F2 | solute carrier family 35, member F2 | 2.758 |
| SLC75A1 | solute carrier family 75 member 1 | 2.74188 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 2.72774 |
| GSTZ1 | glutathione S-transferase zeta 1 | 2.71186 |
| GPC1 | glypican 1 | 2.70569 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | 2.67771 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 2.62182 |
| PRR15L | proline rich 15-like | 2.61677 |
| DSG2 | desmoglein 2 | 2.61337 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 2.61082 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit | 2.59475 |
| RSPH10B2 | radial spoke head 10 homolog B2 (Chlamydomonas) | 2.52364 |
| NANOS3 | nanos homolog 3 (Drosophila) | 2.4717 |
| ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | 2.45457 |
| CDK19 | cyclin-dependent kinase 19 | 2.43862 |
| TOMM34 | translocase of outer mitochondrial membrane 34 | 2.38733 |
| PRKCD | protein kinase C, delta | 2.36786 |
| TMEM212 | transmembrane protein 212 | 2.3611 |
| NNT | nicotinamide nucleotide transhydrogenase | 2.35969 |
| RRP12 | ribosomal RNA processing 12 homolog (S. cerevisiae) | 2.32741 |
| NPC1 | Niemann-Pick disease, type C1 | 2.31069 |
| DIPK1A | divergent protein kinase domain 1A | 2.29558 |
| TRIB1 | tribbles pseudokinase 1 | 2.29521 |
| DUSP2 | dual specificity phosphatase 2 | 2.28901 |
| FZD1 | frizzled class receptor 1 | 2.25647 |
| NMU | neuromedin U | 2.24422 |
| FAM193A | family with sequence similarity 193, member A | 2.24396 |
| TUBB6 | tubulin, beta 6 class V | 2.23142 |
| ACOT9 | acyl-CoA thioesterase 9 | 2.22768 |
| ST18 | suppression of tumorigenicity 18, zinc finger | 2.21423 |
| SSBP2 | single-stranded DNA binding protein 2 | 2.19414 |
| NIBAN1 | niban apoptosis regulator 1 | 2.18811 |
| AARS1 | alanyl-tRNA synthetase 1 | 2.17376 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 2.16931 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | 2.16498 |
| EIF4EBP3 | eukaryotic translation initiation factor 4E binding protein 3 | 2.16042 |
| JADE2 | jade family PHD finger 2 | 2.1592 |
| BZW2 | basic leucine zipper and W2 domains 2 | 2.14637 |
| DUSP6 | dual specificity phosphatase 6 | 2.1324 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 2.12602 |
| CPLANE1 | ciliogenesis and planar polarity effector complex subunit 1 | 2.107 |
| RALB | v-ral simian leukemia viral oncogene homolog B | 2.09496 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 2.08907 |
| SFTPB | surfactant protein B | 2.04369 |
| EVL | Enah/Vasp-like | 2.03809 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 2.01424 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 2.00388 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ISOC1 | isochorismatase domain containing 1 | -8.52526 |
| ZW10 | zw10 kinetochore protein | -6.44244 |
| C5 | complement component 5 | -5.08255 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -4.65143 |
| SOAT2 | sterol O-acyltransferase 2 | -4.58379 |
| ALDOC | aldolase C, fructose-bisphosphate | -4.27054 |
| HSPB1 | heat shock 27kDa protein 1 | -4.19882 |
| PGM1 | phosphoglucomutase 1 | -4.08563 |
| CDC20 | cell division cycle 20 | -3.97576 |
| FGFR4 | fibroblast growth factor receptor 4 | -3.80094 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -3.75086 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -3.63472 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -3.61749 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -3.5565 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -3.48006 |
| POLR1A | polymerase (RNA) I polypeptide A, 194kDa | -3.23027 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | -3.20793 |
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | -3.18267 |
| AURKB | aurora kinase B | -3.10803 |
| CCNB2 | cyclin B2 | -3.10469 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | -3.004 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -2.96474 |
| NR2F6 | nuclear receptor subfamily 2, group F, member 6 | -2.87705 |
| MELK | maternal embryonic leucine zipper kinase | -2.85392 |
| KLHDC2 | kelch domain containing 2 | -2.80633 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -2.80489 |
| ZNF274 | zinc finger protein 274 | -2.80197 |
| TLCD3A | TLC domain containing 3A | -2.76547 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -2.74311 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | -2.72982 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | -2.66126 |
| PGAM4 | phosphoglycerate mutase family member 4 | -2.59748 |
| EIF5 | eukaryotic translation initiation factor 5 | -2.57611 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -2.55469 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | -2.53614 |
| KHK | ketohexokinase (fructokinase) | -2.51767 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -2.47287 |
| STMN1 | stathmin 1 | -2.45999 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | -2.45056 |
| MSH6 | mutS homolog 6 | -2.42865 |
| PREB | prolactin regulatory element binding | -2.41546 |
| TLR4 | toll-like receptor 4 | -2.40402 |
| USP1 | ubiquitin specific peptidase 1 | -2.40106 |
| HTD2 | hydroxyacyl-thioester dehydratase type 2 | -2.39069 |
| ACSM2A | acyl-CoA synthetase medium-chain family member 2A | -2.37456 |
| MSMO1 | methylsterol monooxygenase 1 | -2.35753 |
| FZD7 | frizzled class receptor 7 | -2.35633 |
| DHCR24 | 24-dehydrocholesterol reductase | -2.34435 |
| WASHC4 | WASH complex subunit 4 | -2.33098 |
| TMEM109 | transmembrane protein 109 | -2.30729 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.28156 |
| HMG20B | high mobility group 20B | -2.27848 |
| THAP11 | THAP domain containing 11 | -2.26881 |
| UBR7 | ubiquitin protein ligase E3 component n-recognin 7 (putative) | -2.25376 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | -2.22315 |
| ALDH8A1 | aldehyde dehydrogenase 8 family, member A1 | -2.2038 |
| FICD | FIC domain containing | -2.20362 |
| MLEC | malectin | -2.17666 |
| TTC23 | tetratricopeptide repeat domain 23 | -2.1733 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -2.17078 |
| DERA | deoxyribose-phosphate aldolase (putative) | -2.16115 |
| ALDH4A1 | aldehyde dehydrogenase 4 family, member A1 | -2.12953 |
| BIRC5 | baculoviral IAP repeat containing 5 | -2.12298 |
| TOLLIP | toll interacting protein | -2.11215 |
| PAFAH1B3 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) | -2.11031 |
| PLG | plasminogen | -2.10815 |
| CHMP6 | charged multivesicular body protein 6 | -2.10592 |
| ECH1 | enoyl CoA hydratase 1, peroxisomal | -2.08775 |
| CCNA2 | cyclin A2 | -2.0823 |
| PEG10 | paternally expressed 10 | -2.06158 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -2.04493 |
| ELP5 | elongator acetyltransferase complex subunit 5 | -2.0431 |
| IP6K1 | inositol hexakisphosphate kinase 1 | -2.03585 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -2.02058 |
| NIPSNAP1 | nipsnap homolog 1 (C. elegans) | -2.01916 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -2.01296 |
| ASF1B | anti-silencing function 1B histone chaperone | -2.0126 |
