CRCGN013_HEPG2_24H:B20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description caffeine 20.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

74 genes differentially expressed following the CRCGN013_HEPG2_24H:B20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 7.94398
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 6.77865
PRR15L proline rich 15-like 5.83588
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.5034
CHMP6 charged multivesicular body protein 6 4.80495
CXCL2 chemokine (C-X-C motif) ligand 2 4.68185
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 4.4418
MAMLD1 mastermind-like domain containing 1 4.42202
PPARG peroxisome proliferator-activated receptor gamma 4.40027
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.35033
CCNF cyclin F 4.12641
NOTCH1 notch 1 4.03981
MAP3K4 mitogen-activated protein kinase kinase kinase 4 3.69725
PEX11A peroxisomal biogenesis factor 11 alpha 3.48445
CBR3 carbonyl reductase 3 3.46993
HLA-DRA major histocompatibility complex, class II, DR alpha 3.43344
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.35813
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.31755
LRP10 low density lipoprotein receptor-related protein 10 3.2485
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.0669
UGDH UDP-glucose 6-dehydrogenase 3.03096
NOSIP nitric oxide synthase interacting protein 2.99525
ADRB2 adrenoceptor beta 2, surface 2.95511
CHN1 chimerin 1 2.92962
GPER1 G protein-coupled estrogen receptor 1 2.83249
SNAP25 synaptosomal-associated protein, 25kDa 2.72917
TXNRD1 thioredoxin reductase 1 2.65197
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.5215
ASCC3 activating signal cointegrator 1 complex subunit 3 2.48338
KLHL21 kelch-like family member 21 2.45702
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.36974
MYLK myosin light chain kinase 2.35303
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.35088
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.33024
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.28826
GSTZ1 glutathione S-transferase zeta 1 2.28279
INPP1 inositol polyphosphate-1-phosphatase 2.26145
NXPE3 neurexophilin and PC-esterase domain family, member 3 2.24353
VGLL4 vestigial-like family member 4 2.19616
GPS1 G protein pathway suppressor 1 2.15648
CASC3 cancer susceptibility candidate 3 2.1292
TIAM1 T-cell lymphoma invasion and metastasis 1 2.1195
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 2.08875
PTPRT protein tyrosine phosphatase, receptor type, T 2.03621
WDR6 WD repeat domain 6 2.03475
DCXR dicarbonyl/L-xylulose reductase 2.00055

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -8.29165
CCNB2 cyclin B2 -5.1176
HSPB1 heat shock 27kDa protein 1 -4.99093
NCK1 NCK adaptor protein 1 -4.84754
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.67719
RPS4Y1 ribosomal protein S4, Y-linked 1 -4.6766
PECR peroxisomal trans-2-enoyl-CoA reductase -3.84198
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.60811
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.47271
MAPK13 mitogen-activated protein kinase 13 -3.36232
HMG20B high mobility group 20B -3.34243
EXT1 exostosin glycosyltransferase 1 -3.06177
FGFR4 fibroblast growth factor receptor 4 -3.03502
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.02013
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.96328
KDM3A lysine (K)-specific demethylase 3A -2.96139
CD320 CD320 molecule -2.93121
TM9SF3 transmembrane 9 superfamily member 3 -2.82317
NFIL3 nuclear factor, interleukin 3 regulated -2.78536
RFC2 replication factor C (activator 1) 2, 40kDa -2.73426
TMEM97 transmembrane protein 97 -2.51275
ILK integrin-linked kinase -2.39067
NRIP1 nuclear receptor interacting protein 1 -2.34542
ALDOC aldolase C, fructose-bisphosphate -2.23759
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.08784
PITX1 paired-like homeodomain 1 -2.05541
CCP110 centriolar coiled coil protein 110kDa -2.03887
AMBP alpha-1-microglobulin/bikunin precursor -2.00062