CRCGN013_HEPG2_24H:C03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-nitroanthranilic acid 10.15 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

32 genes differentially expressed following the CRCGN013_HEPG2_24H:C03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 6.93265
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 5.58421
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.92914
LOC122526780 uncharacterized LOC122526780 3.87235
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.73006
CCDC85B coiled-coil domain containing 85B 3.49758
HDGFL3 HDGF like 3 3.42306
CCNF cyclin F 3.4071
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 3.18977
RPP38 ribonuclease P/MRP 38kDa subunit 2.54577
PKN1 protein kinase N1 2.37695
BACE2 beta-site APP-cleaving enzyme 2 2.32959
ZBTB44 zinc finger and BTB domain containing 44 2.23665
NVL nuclear VCP-like 2.22343
HSPA6 heat shock 70kDa protein 6 (HSP70B') 2.20607
MMP1 matrix metallopeptidase 1 2.14781
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.04868

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.31096
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.13142
ANKRD10 ankyrin repeat domain 10 -3.33228
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.31785
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.08254
TM9SF3 transmembrane 9 superfamily member 3 -3.04241
MAP7 microtubule-associated protein 7 -2.83722
FGFR4 fibroblast growth factor receptor 4 -2.68668
TCTN1 tectonic family member 1 -2.57751
WASHC4 WASH complex subunit 4 -2.31891
UBE3C ubiquitin protein ligase E3C -2.21109
CAB39 calcium binding protein 39 -2.12692
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.07271
CCNB2 cyclin B2 -2.04491
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.03107