CRCGN013_HEPG2_24H:C05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-nitroanthranilic acid 2.54 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN013_HEPG2_24H:C05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 7.34438
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.71617
GPER1 G protein-coupled estrogen receptor 1 4.06802
PPARG peroxisome proliferator-activated receptor gamma 4.06176
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.02975
CBR3 carbonyl reductase 3 3.95042
NOTCH1 notch 1 3.88642
MAMLD1 mastermind-like domain containing 1 3.80034
CYCS cytochrome c, somatic 3.2354
HLA-DMA major histocompatibility complex, class II, DM alpha 3.10974
PRR15L proline rich 15-like 3.1007
PEX11A peroxisomal biogenesis factor 11 alpha 2.95403
MINDY1 MINDY lysine 48 deubiquitinase 1 2.86314
HLA-DRA major histocompatibility complex, class II, DR alpha 2.58506
TIAM1 T-cell lymphoma invasion and metastasis 1 2.53853
VGLL4 vestigial-like family member 4 2.30585
CS citrate synthase 2.12902
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 2.11059
MRPL15 mitochondrial ribosomal protein L15 2.05771
CAPN6 calpain 6 2.04132

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -5.56169
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.31542
DNM1L dynamin 1-like -4.19486
MAP7 microtubule-associated protein 7 -3.73375
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.4887
TRIB3 tribbles pseudokinase 3 -3.3439
SMNDC1 survival motor neuron domain containing 1 -3.31113
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.83728
SLC35F2 solute carrier family 35, member F2 -2.65482
MRPS2 mitochondrial ribosomal protein S2 -2.62307
TXNDC9 thioredoxin domain containing 9 -2.52223
TLR4 toll-like receptor 4 -2.46169
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.42616
NT5DC2 5'-nucleotidase domain containing 2 -2.42338
TLCD3A TLC domain containing 3A -2.31133
ZW10 zw10 kinetochore protein -2.27139
CCNB2 cyclin B2 -2.18893
SOWAHC sosondowah ankyrin repeat domain family member C -2.11771
ZNF586 zinc finger protein 586 -2.02733
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.01754