CRCGN013_HEPG2_24H:C11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description paracetamol 2.57 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

87 genes differentially expressed following the CRCGN013_HEPG2_24H:C11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPER1 G protein-coupled estrogen receptor 1 6.84281
CCL2 chemokine (C-C motif) ligand 2 5.41185
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.23453
STK10 serine/threonine kinase 10 4.95142
RPL39L ribosomal protein L39-like 4.92939
NOTCH1 notch 1 4.8309
LCN2 lipocalin 2 4.7464
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.67995
ADRB2 adrenoceptor beta 2, surface 4.67602
C2CD2 C2 calcium-dependent domain containing 2 4.55277
UBQLN2 ubiquilin 2 4.4586
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 4.43023
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.25938
BZW2 basic leucine zipper and W2 domains 2 3.95321
CBR1 carbonyl reductase 1 3.95315
TBP TATA box binding protein 3.90355
MYLK myosin light chain kinase 3.81248
SSBP2 single-stranded DNA binding protein 2 3.39669
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.37109
MELK maternal embryonic leucine zipper kinase 3.15372
ZNF589 zinc finger protein 589 2.98561
CCNA1 cyclin A1 2.90465
CAPN1 calpain 1, (mu/I) large subunit 2.88223
PTK2 protein tyrosine kinase 2 2.82261
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.79235
CEP57 centrosomal protein 57kDa 2.75256
JADE2 jade family PHD finger 2 2.73882
SCYL3 SCY1-like 3 (S. cerevisiae) 2.61772
PRR15L proline rich 15-like 2.49278
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.48935
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.47706
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.41994
LPAR2 lysophosphatidic acid receptor 2 2.41002
MAP7 microtubule-associated protein 7 2.35863
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.30122
HOXB2 homeobox B2 2.27355
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.24012
ZNF33B zinc finger protein 33B 2.18266
SCRN1 secernin 1 2.13956
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.06317

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -5.29559
LOC124907782 dual specificity protein phosphatase 22 -5.00801
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.92602
CAB39 calcium binding protein 39 -4.76352
PHKG2 phosphorylase kinase, gamma 2 (testis) -4.18226
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.09854
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -4.08036
RGS2 regulator of G-protein signaling 2 -4.00809
TCTN1 tectonic family member 1 -3.92752
GLOD4 glyoxalase domain containing 4 -3.7528
ARID5B AT rich interactive domain 5B (MRF1-like) -3.58785
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.48574
FASTKD5 FAST kinase domains 5 -3.18445
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.13641
PIH1D1 PIH1 domain containing 1 -3.1153
MACF1 microtubule-actin crosslinking factor 1 -3.10378
GDF15 growth differentiation factor 15 -3.07272
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.01073
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.84435
STAP2 signal transducing adaptor family member 2 -2.7251
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.62129
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.61266
REEP5 receptor accessory protein 5 -2.44239
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.44107
TWF2 twinfilin actin binding protein 2 -2.34792
KLHL21 kelch-like family member 21 -2.31976
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.2846
MYOM2 myomesin 2 -2.26232
FBXO7 F-box protein 7 -2.26012
HOMER1 homer scaffolding protein 1 -2.2472
SYNGR3 synaptogyrin 3 -2.2041
MVP major vault protein -2.16468
NLRP4 NLR family, pyrin domain containing 4 -2.15972
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) -2.15007
SEPTIN8 septin 8 -2.14746
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.13346
SPAG4 sperm associated antigen 4 -2.12027
NOP16 NOP16 nucleolar protein -2.1147
MTA1 metastasis associated 1 -2.09772
TBC1D10C TBC1 domain family, member 10C -2.03439
TM9SF2 transmembrane 9 superfamily member 2 -2.03228
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -2.03138
GAB2 GRB2-associated binding protein 2 -2.03043
CUL7 cullin 7 -2.01621
THADA thyroid adenoma associated -2.01034
MYL7 myosin, light chain 7, regulatory -2.00964
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.00364