CRCGN013_HEPG2_24H:C12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description paracetamol 1.29 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN013_HEPG2_24H:C12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.49992
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.45029
SSBP2 single-stranded DNA binding protein 2 3.23775
UBQLN2 ubiquilin 2 3.21044
GPATCH8 G patch domain containing 8 3.12878
LCN2 lipocalin 2 2.91547
PLSCR1 phospholipid scramblase 1 2.74271
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.54998
LPAR2 lysophosphatidic acid receptor 2 2.43883
KLHL21 kelch-like family member 21 2.18223
CCNF cyclin F 2.152
FPGS folylpolyglutamate synthase 2.11316
CTTN cortactin 2.0901
SNX7 sorting nexin 7 2.02433
EI24 etoposide induced 2.4 2.0112

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.65903
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.68234
MAP7 microtubule-associated protein 7 -4.20546
FAIM Fas apoptotic inhibitory molecule -3.79905
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.7563
NRIP1 nuclear receptor interacting protein 1 -3.73531
COG7 component of oligomeric golgi complex 7 -3.7126
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.49821
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -3.37585
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.31882
MAPK13 mitogen-activated protein kinase 13 -3.30606
PRPF4 pre-mRNA processing factor 4 -3.27164
FASTKD5 FAST kinase domains 5 -3.25504
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.15505
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.00434
ZNF586 zinc finger protein 586 -2.86775
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.61896
UPK1A uroplakin 1A -2.61283
FBXL12 F-box and leucine-rich repeat protein 12 -2.42564
TMEM268 transmembrane protein 268 -2.19809
ZNF136 zinc finger protein 136 -2.1263
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.11581
TRAPPC6A trafficking protein particle complex 6A -2.01383