CRCGN013_HEPG2_24H:C13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description toluene diisocyanate 40.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN013_HEPG2_24H:C13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PLS1 plastin 1 3.62653
MYLK myosin light chain kinase 3.56596
UBQLN2 ubiquilin 2 3.50498
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.47274
CARMIL1 capping protein regulator and myosin 1 linker 1 3.30015
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.2709
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.25745
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.12944
LCN2 lipocalin 2 2.73592
VAT1 vesicle amine transport 1 2.55341
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.534
LOC122526780 uncharacterized LOC122526780 2.49409
LPAR2 lysophosphatidic acid receptor 2 2.40545
FZD7 frizzled class receptor 7 2.37824
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.35358
LSR lipolysis stimulated lipoprotein receptor 2.29535
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.27319
ANO1 anoctamin 1, calcium activated chloride channel 2.23819
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.236
RIGI RNA sensor RIG-I 2.17376
PMM2 phosphomannomutase 2 2.08596
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.02803
FPGS folylpolyglutamate synthase 2.00166

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -4.9321
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.79276
ZNF586 zinc finger protein 586 -3.75948
PCNA proliferating cell nuclear antigen -3.65806
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.99341
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.83529
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.83484
PTPRK protein tyrosine phosphatase, receptor type, K -2.62627
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.60389
TP53BP2 tumor protein p53 binding protein 2 -2.48478
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.29383
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.2226
TLCD3A TLC domain containing 3A -2.15741
CDC25B cell division cycle 25B -2.14866
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.14414
ANGPTL4 angiopoietin-like 4 -2.07896
HAGH hydroxyacylglutathione hydrolase -2.04694
BATF basic leucine zipper transcription factor, ATF-like -2.0188
SNX11 sorting nexin 11 -2.00146