CRCGN013_HEPG2_24H:C15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description toluene diisocyanate 10.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

52 genes differentially expressed following the CRCGN013_HEPG2_24H:C15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PRR15L proline rich 15-like 4.34749
ADGRE5 adhesion G protein-coupled receptor E5 3.62567
LCN2 lipocalin 2 3.46933
PPARG peroxisome proliferator-activated receptor gamma 3.43499
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.27484
CIAO3 cytosolic iron-sulfur assembly component 3 3.24224
BACE2 beta-site APP-cleaving enzyme 2 3.16917
AMDHD2 amidohydrolase domain containing 2 3.15688
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.09815
HLA-DMA major histocompatibility complex, class II, DM alpha 3.04177
LOC122526780 uncharacterized LOC122526780 3.00001
CARMIL1 capping protein regulator and myosin 1 linker 1 2.97336
CBR3 carbonyl reductase 3 2.9625
E2F2 E2F transcription factor 2 2.85226
HLA-DRA major histocompatibility complex, class II, DR alpha 2.82819
GPER1 G protein-coupled estrogen receptor 1 2.66996
CCNA1 cyclin A1 2.63304
SNAP25 synaptosomal-associated protein, 25kDa 2.60538
EGF epidermal growth factor 2.43892
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 2.31291
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.29964
KIF20A kinesin family member 20A 2.17486
TXNL4B thioredoxin-like 4B 2.05015
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.00618

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -6.84733
CCNB2 cyclin B2 -4.26887
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.63567
ZDHHC6 zinc finger, DHHC-type containing 6 -3.44267
SCAND1 SCAN domain containing 1 -3.20903
ZNF134 zinc finger protein 134 -3.15912
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.12364
C2CD5 C2 calcium-dependent domain containing 5 -3.09946
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.09454
DSG2 desmoglein 2 -3.01848
TRIB3 tribbles pseudokinase 3 -2.95559
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.85663
SLC35F2 solute carrier family 35, member F2 -2.69406
GNAS GNAS complex locus -2.41269
ZNF587B zinc finger protein 587B -2.40934
FGFR4 fibroblast growth factor receptor 4 -2.38476
RNF167 ring finger protein 167 -2.35258
CCNB1 cyclin B1 -2.31347
FASTKD5 FAST kinase domains 5 -2.28105
TLCD3A TLC domain containing 3A -2.24802
EIF5 eukaryotic translation initiation factor 5 -2.23073
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.18135
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.16805
NGRN neugrin, neurite outgrowth associated -2.14858
ZNF587 zinc finger protein 587 -2.13958
ZNF551 zinc finger protein 551 -2.11996
TMEM109 transmembrane protein 109 -2.105
PCNA proliferating cell nuclear antigen -2.06553