CRCGN013_HEPG2_24H:C17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description toluene diisocyanate 2.55 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN013_HEPG2_24H:C17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 5.50055
MAP7 microtubule-associated protein 7 5.30181
INTS3 integrator complex subunit 3 4.95893
PPARG peroxisome proliferator-activated receptor gamma 4.90917
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.65349
CHMP6 charged multivesicular body protein 6 4.61528
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.54878
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.25359
ABHD6 abhydrolase domain containing 6 4.03173
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 3.91567
HLA-DRA major histocompatibility complex, class II, DR alpha 3.9062
MYLK myosin light chain kinase 3.84583
MINDY1 MINDY lysine 48 deubiquitinase 1 3.68334
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 3.59604
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.25301
CHN1 chimerin 1 3.09538
ADGRG1 adhesion G protein-coupled receptor G1 3.07835
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.73007
TBC1D31 TBC1 domain family, member 31 2.72493
GATA2 GATA binding protein 2 2.71102
CGRRF1 cell growth regulator with ring finger domain 1 2.60763
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.57816
TSPAN12 tetraspanin 12 2.31225
RBM15B RNA binding motif protein 15B 2.30988
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like 2.22475
FIG4 FIG4 phosphoinositide 5-phosphatase 2.11036
NCAN neurocan 2.09934
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 2.09298
SLC22A17 solute carrier family 22, member 17 2.07541
STMN4 stathmin-like 4 2.07119
SHROOM2 shroom family member 2 2.06601
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.04584
TRIM46 tripartite motif containing 46 2.01706

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -9.2552
S100A4 S100 calcium binding protein A4 -5.59182
SCAND1 SCAN domain containing 1 -4.73821
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -4.67847
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.43417
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.39797
HSPB1 heat shock 27kDa protein 1 -4.305
SMNDC1 survival motor neuron domain containing 1 -3.93274
RNASE7 ribonuclease, RNase A family, 7 -3.91259
ARID5B AT rich interactive domain 5B (MRF1-like) -3.70136
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.58986
EIF5 eukaryotic translation initiation factor 5 -3.5277
CCNB1 cyclin B1 -3.03353
TRAP1 TNF receptor-associated protein 1 -2.9867
RGS2 regulator of G-protein signaling 2 -2.92133
NGRN neugrin, neurite outgrowth associated -2.4893
NCOA6 nuclear receptor coactivator 6 -2.26494
CAB39 calcium binding protein 39 -2.21595
TEX10 testis expressed 10 -2.19107
ILK integrin-linked kinase -2.16289
TLR4 toll-like receptor 4 -2.12512
CCP110 centriolar coiled coil protein 110kDa -2.04254
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) -2.04131
PALMD palmdelphin -2.02389
RHOC ras homolog family member C -2.0198
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 -2.00828