CRCGN013_HEPG2_24H:D01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tretinoin 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

149 genes differentially expressed following the CRCGN013_HEPG2_24H:D01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GFOD1 glucose-fructose oxidoreductase domain containing 1 8.15872
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 5.70998
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 5.59557
GPER1 G protein-coupled estrogen receptor 1 4.95058
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 4.87511
ANO10 anoctamin 10 4.74186
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.12309
E2F2 E2F transcription factor 2 4.00215
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.94467
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 3.92141
HOXA5 homeobox A5 3.82638
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.82617
BACE2 beta-site APP-cleaving enzyme 2 3.55826
HLA-DMA major histocompatibility complex, class II, DM alpha 3.53669
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 3.51135
DNMT1 DNA (cytosine-5-)-methyltransferase 1 3.46035
MAMLD1 mastermind-like domain containing 1 3.45294
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.37485
ATP11B ATPase, class VI, type 11B 3.35162
TRIB3 tribbles pseudokinase 3 3.29857
CYCS cytochrome c, somatic 3.27806
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.26979
BPHL biphenyl hydrolase-like (serine hydrolase) 3.25606
MYLK myosin light chain kinase 3.12301
DDIT4 DNA-damage-inducible transcript 4 3.10859
SNX7 sorting nexin 7 3.08136
ADAT1 adenosine deaminase, tRNA-specific 1 2.94745
ABHD4 abhydrolase domain containing 4 2.90653
MSRA methionine sulfoxide reductase A 2.84324
CCL2 chemokine (C-C motif) ligand 2 2.82065
ANKRD34C ankyrin repeat domain 34C 2.70272
SYNE2 spectrin repeat containing, nuclear envelope 2 2.68023
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.65369
TBC1D31 TBC1 domain family, member 31 2.57755
SULF1 sulfatase 1 2.56684
MAGEC1 melanoma antigen family C1 2.55634
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.55449
HMOX1 heme oxygenase 1 2.52182
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.50865
FCHO1 FCH domain only 1 2.49708
ECH1 enoyl CoA hydratase 1, peroxisomal 2.46888
SPACA1 sperm acrosome associated 1 2.41567
GATA3 GATA binding protein 3 2.37456
ZNF589 zinc finger protein 589 2.36495
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 2.36379
MYO16 myosin XVI 2.35549
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 2.34326
CDPF1 cysteine-rich, DPF motif domain containing 1 2.30823
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.30221
PPARG peroxisome proliferator-activated receptor gamma 2.29773
SLC30A3 solute carrier family 30 (zinc transporter), member 3 2.29734
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.29293
KRT24 keratin 24, type I 2.27774
TIAM1 T-cell lymphoma invasion and metastasis 1 2.2755
DIAPH3 diaphanous-related formin 3 2.25706
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.23925
GRIA4 glutamate receptor, ionotropic, AMPA 4 2.23738
PACC1 proton activated chloride channel 1 2.22794
DGKI diacylglycerol kinase, iota 2.21741
BCO1 beta-carotene oxygenase 1 2.20917
HEBP1 heme binding protein 1 2.20505
NUP133 nucleoporin 133kDa 2.19994
MYBPH myosin binding protein H 2.19393
CCNF cyclin F 2.18596
GRM6 glutamate receptor, metabotropic 6 2.15929
CNKSR2 connector enhancer of kinase suppressor of Ras 2 2.15696
NMBR neuromedin B receptor 2.15585
CCDC92 coiled-coil domain containing 92 2.15099
SSPN sarcospan 2.14487
GFRA1 GDNF family receptor alpha 1 2.14135
SLITRK2 SLIT and NTRK-like family, member 2 2.13427
PRICKLE3 prickle homolog 3 (Drosophila) 2.12693
CHN1 chimerin 1 2.12452
PYGL phosphorylase, glycogen, liver 2.11917
PLA2G4B phospholipase A2, group IVB (cytosolic) 2.10821
ADAM18 ADAM metallopeptidase domain 18 2.10447
FOS FBJ murine osteosarcoma viral oncogene homolog 2.10418
GPR22 G protein-coupled receptor 22 2.1032
TTC13 tetratricopeptide repeat domain 13 2.10263
TXNRD1 thioredoxin reductase 1 2.09908
MID2 midline 2 2.0988
LOC124907782 dual specificity protein phosphatase 22 2.08189
TMPRSS5 transmembrane protease, serine 5 2.08118
ANKRD55 ankyrin repeat domain 55 2.0728
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) 2.0598
MAGIX MAGI family member, X-linked 2.05412
EXOC6B exocyst complex component 6B 2.05281
TAS2R13 taste receptor, type 2, member 13 2.05106
ALX3 ALX homeobox 3 2.04873
ALAS1 5'-aminolevulinate synthase 1 2.04468
GARRE1 granule associated Rac and RHOG effector 1 2.04003
FEZF2 FEZ family zinc finger 2 2.02297
BHLHE41 basic helix-loop-helix family, member e41 2.02216
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 2.02132
IFFO1 intermediate filament family orphan 1 2.0184
MAGEA11 melanoma antigen family A11 2.01508
MINDY1 MINDY lysine 48 deubiquitinase 1 2.01141
MAGEB3 melanoma antigen family B3 2.00494
SOCS2 suppressor of cytokine signaling 2 2.00186
IKZF2 IKAROS family zinc finger 2 (Helios) 2.00169

decreased expression

Symbol Name Standardized Value
NGRN neugrin, neurite outgrowth associated -6.42129
DUSP6 dual specificity phosphatase 6 -4.98755
MAPK13 mitogen-activated protein kinase 13 -4.91174
ILK integrin-linked kinase -4.62832
TLCD3A TLC domain containing 3A -4.53174
IER3 immediate early response 3 -3.81938
INPP1 inositol polyphosphate-1-phosphatase -3.63748
LDHD lactate dehydrogenase D -3.62394
ZNF586 zinc finger protein 586 -3.55471
ZMIZ1 zinc finger, MIZ-type containing 1 -3.43943
OXA1L oxidase (cytochrome c) assembly 1-like -3.43167
ZW10 zw10 kinetochore protein -3.41908
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.39872
KDM3A lysine (K)-specific demethylase 3A -3.35577
CDC20 cell division cycle 20 -3.01043
S100A4 S100 calcium binding protein A4 -2.99815
TOMM34 translocase of outer mitochondrial membrane 34 -2.87754
DCK deoxycytidine kinase -2.81792
FOXO4 forkhead box O4 -2.79786
VDAC1 voltage-dependent anion channel 1 -2.78201
POLR1D polymerase (RNA) I polypeptide D, 16kDa -2.73649
SLC35F2 solute carrier family 35, member F2 -2.72009
NUP85 nucleoporin 85kDa -2.62332
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.57574
USP6NL USP6 N-terminal like -2.55711
TXNDC9 thioredoxin domain containing 9 -2.5525
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.53335
MVP major vault protein -2.52051
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) -2.47058
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -2.46751
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.4318
CCNB2 cyclin B2 -2.40546
ZNF274 zinc finger protein 274 -2.38388
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -2.35746
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.32754
GLRX glutaredoxin (thioltransferase) -2.32094
MRPS18A mitochondrial ribosomal protein S18A -2.24178
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -2.22756
CDK1 cyclin-dependent kinase 1 -2.21211
PGAM4 phosphoglycerate mutase family member 4 -2.2112
SYK spleen tyrosine kinase -2.19842
HMGA2 high mobility group AT-hook 2 -2.19292
DERA deoxyribose-phosphate aldolase (putative) -2.17948
REEP5 receptor accessory protein 5 -2.14461
TCTN1 tectonic family member 1 -2.12568
EGF epidermal growth factor -2.07353
ZNHIT2 zinc finger, HIT-type containing 2 -2.05027
TUBB6 tubulin, beta 6 class V -2.04909
PROS1 protein S (alpha) -2.03807