CRCGN013_HEPG2_24H:D02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tretinoin 20.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

67 genes differentially expressed following the CRCGN013_HEPG2_24H:D02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HOXA5 homeobox A5 4.18661
GFOD1 glucose-fructose oxidoreductase domain containing 1 4.14293
AMDHD2 amidohydrolase domain containing 2 3.66578
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 3.61022
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.60543
ADRB2 adrenoceptor beta 2, surface 3.53039
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 3.50838
LCN2 lipocalin 2 3.50453
RPL39L ribosomal protein L39-like 3.39755
LOC122526780 uncharacterized LOC122526780 3.31184
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.2669
ECH1 enoyl CoA hydratase 1, peroxisomal 3.20411
HMOX1 heme oxygenase 1 3.12204
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.99776
CXCR4 chemokine (C-X-C motif) receptor 4 2.65611
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.64258
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.57691
KIFBP kinesin family binding protein 2.42002
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.37526
MAP7 microtubule-associated protein 7 2.36727
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.34595
DDIT4 DNA-damage-inducible transcript 4 2.30471
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.22431
HYOU1 hypoxia up-regulated 1 2.21074
GPER1 G protein-coupled estrogen receptor 1 2.15752
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.11557
SAE1 SUMO1 activating enzyme subunit 1 2.11102
GLYAT glycine-N-acyltransferase 2.07453

decreased expression

Symbol Name Standardized Value
TRIB3 tribbles pseudokinase 3 -6.20952
OXA1L oxidase (cytochrome c) assembly 1-like -5.34251
LOC124907782 dual specificity protein phosphatase 22 -5.00088
DUSP6 dual specificity phosphatase 6 -4.77767
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.28895
CAB39 calcium binding protein 39 -4.01744
IER3 immediate early response 3 -3.83735
INPP1 inositol polyphosphate-1-phosphatase -3.66237
FAT1 FAT atypical cadherin 1 -3.11346
ELAC2 elaC ribonuclease Z 2 -3.08297
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -2.90855
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.87099
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.81985
NRIP1 nuclear receptor interacting protein 1 -2.75972
TM9SF2 transmembrane 9 superfamily member 2 -2.64899
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.62678
FOS FBJ murine osteosarcoma viral oncogene homolog -2.60564
TM9SF3 transmembrane 9 superfamily member 3 -2.60033
GLRX glutaredoxin (thioltransferase) -2.5837
USP6NL USP6 N-terminal like -2.56972
ZNF586 zinc finger protein 586 -2.56138
GNAS GNAS complex locus -2.5563
PTPRK protein tyrosine phosphatase, receptor type, K -2.55378
FOXO4 forkhead box O4 -2.46099
HMGA2 high mobility group AT-hook 2 -2.41435
POLR1D polymerase (RNA) I polypeptide D, 16kDa -2.40768
PLS1 plastin 1 -2.38395
EGR1 early growth response 1 -2.35284
TUBB6 tubulin, beta 6 class V -2.26138
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.25013
PPARG peroxisome proliferator-activated receptor gamma -2.21051
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.15969
TXNDC9 thioredoxin domain containing 9 -2.10621
SNX11 sorting nexin 11 -2.07812
FASTKD5 FAST kinase domains 5 -2.06255
EDN1 endothelin 1 -2.05986
UBE3C ubiquitin protein ligase E3C -2.05433
RAP1GAP RAP1 GTPase activating protein -2.05271
CHIC2 cysteine-rich hydrophobic domain 2 -2.03098