CRCGN013_HEPG2_24H:D04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tretinoin 5.03 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

90 genes differentially expressed following the CRCGN013_HEPG2_24H:D04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 7.04514
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.47656
RRAGA Ras-related GTP binding A 4.30802
CHN1 chimerin 1 4.24998
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 4.19299
LCN2 lipocalin 2 3.76094
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.71118
BACE2 beta-site APP-cleaving enzyme 2 3.63238
MYLK myosin light chain kinase 3.56478
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.38601
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 3.37047
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 3.24727
STK10 serine/threonine kinase 10 3.13786
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.10625
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.10054
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 2.9857
ATP11B ATPase, class VI, type 11B 2.9825
PARP2 poly (ADP-ribose) polymerase 2 2.95171
HMOX1 heme oxygenase 1 2.93774
MAMLD1 mastermind-like domain containing 1 2.9024
MCM3 minichromosome maintenance complex component 3 2.88215
KIFBP kinesin family binding protein 2.83883
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.76543
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.73992
PDLIM1 PDZ and LIM domain 1 2.7257
EPM2AIP1 EPM2A (laforin) interacting protein 1 2.65566
ECH1 enoyl CoA hydratase 1, peroxisomal 2.63151
KLHDC2 kelch domain containing 2 2.53568
DENND2D DENN/MADD domain containing 2D 2.51119
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.44733
SFTPB surfactant protein B 2.44536
HYOU1 hypoxia up-regulated 1 2.44094
TDO2 tryptophan 2,3-dioxygenase 2.2659
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 2.25003
CDPF1 cysteine-rich, DPF motif domain containing 1 2.16351
NIPSNAP1 nipsnap homolog 1 (C. elegans) 2.15479
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.15466
WFS1 Wolfram syndrome 1 (wolframin) 2.14275
HOXA5 homeobox A5 2.13554
TMEM214 transmembrane protein 214 2.13255
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 2.12061
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.11832
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.0934
GABARAP GABA(A) receptor-associated protein 2.06972
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.04677
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.03663
MINDY1 MINDY lysine 48 deubiquitinase 1 2.03181
ANO1 anoctamin 1, calcium activated chloride channel 2.00869

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.4447
DUSP6 dual specificity phosphatase 6 -5.13184
CAB39 calcium binding protein 39 -4.58249
ACOT9 acyl-CoA thioesterase 9 -4.49046
ARID5B AT rich interactive domain 5B (MRF1-like) -4.35332
LOC124907782 dual specificity protein phosphatase 22 -3.90826
INPP1 inositol polyphosphate-1-phosphatase -3.89574
FBXL12 F-box and leucine-rich repeat protein 12 -3.73701
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.68607
FAT1 FAT atypical cadherin 1 -3.49642
PCCB propionyl CoA carboxylase, beta polypeptide -3.47548
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -3.47387
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -3.40103
HMGA2 high mobility group AT-hook 2 -3.34523
EDN1 endothelin 1 -3.32626
CCNB2 cyclin B2 -3.18998
UBE3C ubiquitin protein ligase E3C -3.12265
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.06664
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.02869
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.98029
GLRX glutaredoxin (thioltransferase) -2.9095
IER3 immediate early response 3 -2.80337
MVP major vault protein -2.80163
USP6NL USP6 N-terminal like -2.78591
AKAP8 A kinase (PRKA) anchor protein 8 -2.74434
RAI14 retinoic acid induced 14 -2.69789
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.60476
PLS1 plastin 1 -2.59539
S100A4 S100 calcium binding protein A4 -2.55205
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.52285
TXNRD1 thioredoxin reductase 1 -2.506
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -2.44884
DSG2 desmoglein 2 -2.44688
PPARG peroxisome proliferator-activated receptor gamma -2.30376
UGDH UDP-glucose 6-dehydrogenase -2.29776
KLHL21 kelch-like family member 21 -2.23001
COG2 component of oligomeric golgi complex 2 -2.20064
CDC45 cell division cycle 45 -2.13499
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F -2.1181
BLCAP bladder cancer associated protein -2.11316
EMP1 epithelial membrane protein 1 -2.08206
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.0515