CRCGN013_HEPG2_24H:D06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tretinoin 1.26 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

54 genes differentially expressed following the CRCGN013_HEPG2_24H:D06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 5.82848
UBQLN2 ubiquilin 2 3.75656
CIAO3 cytosolic iron-sulfur assembly component 3 3.72384
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 3.47172
NSDHL NAD(P) dependent steroid dehydrogenase-like 3.21519
HOXA5 homeobox A5 3.13749
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 3.11982
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.83606
PDLIM1 PDZ and LIM domain 1 2.78051
DYNLT3 dynein, light chain, Tctex-type 3 2.71573
KLHDC2 kelch domain containing 2 2.71569
ECH1 enoyl CoA hydratase 1, peroxisomal 2.68667
GPER1 G protein-coupled estrogen receptor 1 2.55245
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.54993
SIRT3 sirtuin 3 2.50554
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.40479
HMOX1 heme oxygenase 1 2.25872
SFTPB surfactant protein B 2.25741
LOC122526780 uncharacterized LOC122526780 2.22074
PARP2 poly (ADP-ribose) polymerase 2 2.22051
DDIT4 DNA-damage-inducible transcript 4 2.21974
VAV3 vav 3 guanine nucleotide exchange factor 2.03072

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -5.04426
DUSP6 dual specificity phosphatase 6 -4.18333
INPP1 inositol polyphosphate-1-phosphatase -4.04711
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -3.44015
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.42686
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.34366
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -3.25145
VAT1 vesicle amine transport 1 -3.1026
HSPB1 heat shock 27kDa protein 1 -3.08363
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.97171
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.94463
USP6NL USP6 N-terminal like -2.89623
TLCD3A TLC domain containing 3A -2.83983
MVP major vault protein -2.79377
LDHD lactate dehydrogenase D -2.7848
IER3 immediate early response 3 -2.77291
SLC35F2 solute carrier family 35, member F2 -2.71125
TM9SF3 transmembrane 9 superfamily member 3 -2.68304
CDC20 cell division cycle 20 -2.65424
GLRX glutaredoxin (thioltransferase) -2.59891
OXA1L oxidase (cytochrome c) assembly 1-like -2.57381
S100A4 S100 calcium binding protein A4 -2.24837
CCNB1 cyclin B1 -2.23046
CHMP4B charged multivesicular body protein 4B -2.22778
PCNA proliferating cell nuclear antigen -2.12265
LMTK1 lemur tail kinase 1 -2.11345
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) -2.06648
MED15 mediator complex subunit 15 -2.05423
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.05004
FAT1 FAT atypical cadherin 1 -2.03004
UGDH UDP-glucose 6-dehydrogenase -2.02681
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.02609