CRCGN013_HEPG2_24H:D09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-chloro-p-phenylenediamine sulfate 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

132 genes differentially expressed following the CRCGN013_HEPG2_24H:D09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 6.73652
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.46978
LCN2 lipocalin 2 6.45971
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 5.87767
CARMIL1 capping protein regulator and myosin 1 linker 1 5.60835
CDPF1 cysteine-rich, DPF motif domain containing 1 5.47227
UGDH UDP-glucose 6-dehydrogenase 4.76535
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 4.53543
HLA-DMA major histocompatibility complex, class II, DM alpha 4.45222
HMOX1 heme oxygenase 1 4.42644
CHN1 chimerin 1 4.19645
JADE2 jade family PHD finger 2 4.08887
CBR1 carbonyl reductase 1 3.96784
VAT1 vesicle amine transport 1 3.93492
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.90889
MAP7 microtubule-associated protein 7 3.90475
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.84243
TXNL4B thioredoxin-like 4B 3.7728
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 3.53922
PLS1 plastin 1 3.48896
SQSTM1 sequestosome 1 3.3368
TBPL1 TBP-like 1 3.24156
OXCT1 3-oxoacid CoA transferase 1 3.08406
BZW2 basic leucine zipper and W2 domains 2 3.08327
TAC4 tachykinin 4 (hemokinin) 3.0654
STIMATE STIM activating enhancer 2.92859
LOXL1 lysyl oxidase-like 1 2.91181
INPP1 inositol polyphosphate-1-phosphatase 2.89168
INSIG1 insulin induced gene 1 2.88553
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.87145
CBR3 carbonyl reductase 3 2.85555
RAP1GAP RAP1 GTPase activating protein 2.83491
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.79522
ABHD4 abhydrolase domain containing 4 2.7747
UBQLN2 ubiquilin 2 2.74474
CXCL2 chemokine (C-X-C motif) ligand 2 2.66301
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.63706
MYLK myosin light chain kinase 2.63153
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.61896
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.61105
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.60888
HSPA1A heat shock 70kDa protein 1A 2.59168
STX1A syntaxin 1A (brain) 2.56892
AKR1C3 aldo-keto reductase family 1, member C3 2.48832
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.47945
KEAP1 kelch-like ECH-associated protein 1 2.45945
ADGRE5 adhesion G protein-coupled receptor E5 2.44497
FHL2 four and a half LIM domains 2 2.4307
LSR lipolysis stimulated lipoprotein receptor 2.42359
ANO10 anoctamin 10 2.42141
AKR1C1 aldo-keto reductase family 1, member C1 2.3794
GPC1 glypican 1 2.34123
SATB1 SATB homeobox 1 2.30585
DYNLT3 dynein, light chain, Tctex-type 3 2.29978
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.28981
SQOR sulfide quinone oxidoreductase 2.26232
PLPP2 phospholipid phosphatase 2 2.26045
SCRN1 secernin 1 2.25636
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.2533
PARP1 poly (ADP-ribose) polymerase 1 2.2328
FUCA1 fucosidase, alpha-L- 1, tissue 2.22783
TALDO1 transaldolase 1 2.21492
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.20536
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.20241
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.1952
DHDDS dehydrodolichyl diphosphate synthase 2.17511
GSTZ1 glutathione S-transferase zeta 1 2.16449
GSR glutathione reductase 2.15977
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 2.14234
GCLM glutamate-cysteine ligase, modifier subunit 2.13913
CES1 carboxylesterase 1 2.13876
HEBP2 heme binding protein 2 2.09454
PPARG peroxisome proliferator-activated receptor gamma 2.062
TCTN3 tectonic family member 3 2.03006
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.02657
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.00989
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 2.00008

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -6.77311
MRPS2 mitochondrial ribosomal protein S2 -6.45571
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -5.27542
TRIB3 tribbles pseudokinase 3 -4.4361
C5 complement component 5 -4.35485
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.24025
ALDOC aldolase C, fructose-bisphosphate -4.21773
ZNF586 zinc finger protein 586 -4.19862
B4GAT1 beta-1,4-glucuronyltransferase 1 -3.93055
COG2 component of oligomeric golgi complex 2 -3.72673
TLCD3A TLC domain containing 3A -3.62753
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.49379
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.44124
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.36012
GTPBP8 GTP-binding protein 8 (putative) -3.31252
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.2567
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -3.23586
FASTKD5 FAST kinase domains 5 -3.22517
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.2038
TM9SF2 transmembrane 9 superfamily member 2 -3.1908
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -3.17625
LDHD lactate dehydrogenase D -3.15468
CCNB2 cyclin B2 -3.04501
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.04258
ZW10 zw10 kinetochore protein -2.91594
PCNA proliferating cell nuclear antigen -2.90468
C2CD5 C2 calcium-dependent domain containing 5 -2.88174
OXA1L oxidase (cytochrome c) assembly 1-like -2.86307
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.80226
TM9SF3 transmembrane 9 superfamily member 3 -2.78875
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -2.67711
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.65567
UBE3C ubiquitin protein ligase E3C -2.57815
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.57576
MRPS16 mitochondrial ribosomal protein S16 -2.57377
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.52986
FAT1 FAT atypical cadherin 1 -2.34286
HMG20B high mobility group 20B -2.32076
TOP2A topoisomerase (DNA) II alpha 170kDa -2.28473
LAP3 leucine aminopeptidase 3 -2.27335
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.26342
DDIT4 DNA-damage-inducible transcript 4 -2.26333
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.22396
HPS6 Hermansky-Pudlak syndrome 6 -2.20875
RBM41 RNA binding motif protein 41 -2.18338
TENT4A terminal nucleotidyltransferase 4A -2.16258
FBXL6 F-box and leucine-rich repeat protein 6 -2.10779
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -2.08807
TM4SF5 transmembrane 4 L six family member 5 -2.07582
GNAS GNAS complex locus -2.06426
CHIC2 cysteine-rich hydrophobic domain 2 -2.0627
JMJD4 jumonji domain containing 4 -2.06153
TLR4 toll-like receptor 4 -2.0503
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.04854
GFRA1 GDNF family receptor alpha 1 -2.02249