CRCGN013_HEPG2_24H:D16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dimethyl terephthalate 5.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

64 genes differentially expressed following the CRCGN013_HEPG2_24H:D16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPER1 G protein-coupled estrogen receptor 1 4.54623
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 4.54084
PLS1 plastin 1 4.53781
LCN2 lipocalin 2 3.98019
RPP38 ribonuclease P/MRP 38kDa subunit 3.96209
CHMP6 charged multivesicular body protein 6 3.87692
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.80178
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.76538
PPARG peroxisome proliferator-activated receptor gamma 3.68881
CXCL2 chemokine (C-X-C motif) ligand 2 3.60452
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.51231
C2CD2 C2 calcium-dependent domain containing 2 3.38785
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 3.32791
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.2043
NFIL3 nuclear factor, interleukin 3 regulated 3.17886
MAP3K4 mitogen-activated protein kinase kinase kinase 4 3.03266
MAP7 microtubule-associated protein 7 3.03228
TBP TATA box binding protein 3.00324
STIMATE STIM activating enhancer 2.99558
E2F2 E2F transcription factor 2 2.93775
TIAM1 T-cell lymphoma invasion and metastasis 1 2.86955
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.78448
FZD7 frizzled class receptor 7 2.7685
CYCS cytochrome c, somatic 2.68613
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.57014
CHEK2 checkpoint kinase 2 2.52579
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) 2.40156
SATB1 SATB homeobox 1 2.36156
ANO1 anoctamin 1, calcium activated chloride channel 2.3553
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.3444
CIAO3 cytosolic iron-sulfur assembly component 3 2.33761
HLA-DRA major histocompatibility complex, class II, DR alpha 2.30546
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.29805
MCM9 minichromosome maintenance complex component 9 2.25644
CHN1 chimerin 1 2.22038
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.16665
STK10 serine/threonine kinase 10 2.11087
ZNF143 zinc finger protein 143 2.08629
PSAT1 phosphoserine aminotransferase 1 2.06035
NOTCH1 notch 1 2.03303
COPS7A COP9 signalosome subunit 7A 2.01223

decreased expression

Symbol Name Standardized Value
MAPK13 mitogen-activated protein kinase 13 -7.16466
PCNA proliferating cell nuclear antigen -5.84724
GNAS GNAS complex locus -5.63676
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.17793
CCNB1 cyclin B1 -3.79628
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.64379
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.59703
CHMP4B charged multivesicular body protein 4B -3.55889
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.49146
YME1L1 YME1-like 1 ATPase -3.4356
LDHD lactate dehydrogenase D -3.42513
JMJD6 jumonji domain containing 6 -2.85994
MRPS2 mitochondrial ribosomal protein S2 -2.73202
HMG20B high mobility group 20B -2.67851
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.66461
TMEM109 transmembrane protein 109 -2.65233
RHEB Ras homolog enriched in brain -2.43398
KIF21B kinesin family member 21B -2.29014
UGDH UDP-glucose 6-dehydrogenase -2.26531
NRIP1 nuclear receptor interacting protein 1 -2.24303
OXA1L oxidase (cytochrome c) assembly 1-like -2.1859
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.17852
ARHGAP1 Rho GTPase activating protein 1 -2.11502