CRCGN013_HEPG2_24H:D17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dimethyl terephthalate 2.52 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN013_HEPG2_24H:D17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PLS1 plastin 1 9.1084
UBQLN2 ubiquilin 2 4.76433
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 4.17354
LCN2 lipocalin 2 4.16542
PROS1 protein S (alpha) 3.05426
CHN1 chimerin 1 3.04642
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.94193
SFTPB surfactant protein B 2.93515
GPATCH8 G patch domain containing 8 2.87311
SIRT3 sirtuin 3 2.80163
TIAM1 T-cell lymphoma invasion and metastasis 1 2.67754
EGF epidermal growth factor 2.52574
EVL Enah/Vasp-like 2.31605
NPIPB5 nuclear pore complex interacting protein family, member B5 2.14591
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.13227
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.10108
SLC38A10 solute carrier family 38, member 10 2.02489
GNG7 guanine nucleotide binding protein (G protein), gamma 7 2.02415
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.01242
TUBB2B tubulin, beta 2B class IIb 2.01139

decreased expression

Symbol Name Standardized Value
TRIB3 tribbles pseudokinase 3 -4.83709
NT5DC2 5'-nucleotidase domain containing 2 -4.77298
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.56133
LDHD lactate dehydrogenase D -4.54479
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.16171
TWF2 twinfilin actin binding protein 2 -3.39887
CCNB2 cyclin B2 -3.25627
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -3.11026
TNIP1 TNFAIP3 interacting protein 1 -2.73011
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.72234
SNX11 sorting nexin 11 -2.70523
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.6706
BLCAP bladder cancer associated protein -2.53357
TLR4 toll-like receptor 4 -2.39698
CPNE3 copine III -2.35537
RGS2 regulator of G-protein signaling 2 -2.2929
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha -2.29
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.27368
LOC124907782 dual specificity protein phosphatase 22 -2.21102
PRPF4 pre-mRNA processing factor 4 -2.19514
NRIP1 nuclear receptor interacting protein 1 -2.00331