CRCGN013_HEPG2_24H:D20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description trichlorofluoromethane 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

68 genes differentially expressed following the CRCGN013_HEPG2_24H:D20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 9.07507
LOC122526780 uncharacterized LOC122526780 5.74147
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 5.42525
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 4.73728
ADGRE5 adhesion G protein-coupled receptor E5 4.67728
E2F2 E2F transcription factor 2 4.64303
MYLK myosin light chain kinase 4.62343
LCN2 lipocalin 2 4.53754
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.47423
CYCS cytochrome c, somatic 4.3693
PPARG peroxisome proliferator-activated receptor gamma 4.29689
CBR3 carbonyl reductase 3 4.23585
C2CD2 C2 calcium-dependent domain containing 2 4.16871
SYNE2 spectrin repeat containing, nuclear envelope 2 4.11548
SNAP25 synaptosomal-associated protein, 25kDa 4.02329
STIMATE STIM activating enhancer 3.99266
UBQLN2 ubiquilin 2 3.97894
SSBP2 single-stranded DNA binding protein 2 3.84622
GPER1 G protein-coupled estrogen receptor 1 3.76623
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.63894
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.536
FZD7 frizzled class receptor 7 3.10731
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.08096
NOSIP nitric oxide synthase interacting protein 3.01979
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.83412
CD40 CD40 molecule, TNF receptor superfamily member 5 2.74861
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 2.68093
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.60536
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.55403
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) 2.4113
WDTC1 WD and tetratricopeptide repeats 1 2.33243
SLC38A6 solute carrier family 38, member 6 2.31189
ATAD3A ATPase family, AAA domain containing 3A 2.30409
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.20465
CDC45 cell division cycle 45 2.13726
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 2.10458
CD1B CD1b molecule 2.08408
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.07711
CFAP44 cilia and flagella associated protein 44 2.07069
TOGARAM1 TOG array regulator of axonemal microtubules 1 2.04426
RABAC1 Rab acceptor 1 (prenylated) 2.01956

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -9.07671
GNAS GNAS complex locus -6.58355
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -5.03527
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.65405
CASP3 caspase 3, apoptosis-related cysteine peptidase -4.40317
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.2514
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.09509
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.96138
DSG2 desmoglein 2 -3.83744
PCNA proliferating cell nuclear antigen -3.77437
DNM1L dynamin 1-like -3.64664
MAPK13 mitogen-activated protein kinase 13 -3.1031
EIF5 eukaryotic translation initiation factor 5 -3.09763
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.0561
TMEM109 transmembrane protein 109 -3.04253
STAMBP STAM binding protein -2.80523
NRIP1 nuclear receptor interacting protein 1 -2.60719
SNX11 sorting nexin 11 -2.54817
WDR26 WD repeat domain 26 -2.41024
TM9SF3 transmembrane 9 superfamily member 3 -2.35763
NUP62 nucleoporin 62kDa -2.34054
ZMIZ1 zinc finger, MIZ-type containing 1 -2.31665
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -2.19071
NTM neurotrimin -2.10633
GLYAT glycine-N-acyltransferase -2.07922
VNN1 vanin 1 -2.01499
EXT1 exostosin glycosyltransferase 1 -2.00003