CRCGN013_HEPG2_24H:D21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description trichlorofluoromethane 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN013_HEPG2_24H:D21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHN1 chimerin 1 6.58152
SSBP2 single-stranded DNA binding protein 2 6.25753
CDPF1 cysteine-rich, DPF motif domain containing 1 6.25259
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.56955
GPER1 G protein-coupled estrogen receptor 1 4.40874
GATA3 GATA binding protein 3 3.83356
SNX7 sorting nexin 7 3.35557
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.98101
ADAT1 adenosine deaminase, tRNA-specific 1 2.88261
CYCS cytochrome c, somatic 2.66155
HLA-DMA major histocompatibility complex, class II, DM alpha 2.62545
H2BC12 H2B clustered histone 12 2.35334
GSTZ1 glutathione S-transferase zeta 1 2.35034
LRP10 low density lipoprotein receptor-related protein 10 2.32162
TIAM1 T-cell lymphoma invasion and metastasis 1 2.23964
TP53 tumor protein p53 2.16623
NOTCH1 notch 1 2.14699
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.06737
CUTC cutC copper transporter 2.04977

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -5.88892
CD320 CD320 molecule -4.83681
GNAS GNAS complex locus -4.65874
C2CD5 C2 calcium-dependent domain containing 5 -4.39601
GOLT1B golgi transport 1B -4.29697
ZNF586 zinc finger protein 586 -3.83768
ZW10 zw10 kinetochore protein -3.6758
MRPS2 mitochondrial ribosomal protein S2 -3.48893
DNM1L dynamin 1-like -3.389
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.85531
CSNK1E casein kinase 1, epsilon -2.84418
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.79251
TLR4 toll-like receptor 4 -2.76733
ARID5B AT rich interactive domain 5B (MRF1-like) -2.6834
UBE3C ubiquitin protein ligase E3C -2.5561
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.49284
ZNF280D zinc finger protein 280D -2.49036
CDC20 cell division cycle 20 -2.48297
ETNK1 ethanolamine kinase 1 -2.43079
OXA1L oxidase (cytochrome c) assembly 1-like -2.21701
PARP6 poly (ADP-ribose) polymerase family, member 6 -2.21384
RESF1 retroelement silencing factor 1 -2.013
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.01022