CRCGN013_HEPG2_24H:D24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description trichlorofluoromethane 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN013_HEPG2_24H:D24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.01179
ADRB2 adrenoceptor beta 2, surface 4.91028
E2F2 E2F transcription factor 2 4.88208
PLS1 plastin 1 4.70766
HLA-DMA major histocompatibility complex, class II, DM alpha 4.59073
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.41414
UBQLN2 ubiquilin 2 4.36071
PNKP polynucleotide kinase 3'-phosphatase 4.16862
FZD7 frizzled class receptor 7 3.82721
NOSIP nitric oxide synthase interacting protein 3.58014
GPER1 G protein-coupled estrogen receptor 1 3.37035
LCN2 lipocalin 2 3.36415
GSTZ1 glutathione S-transferase zeta 1 3.29133
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.04112
EPHA3 EPH receptor A3 2.67439
ANO1 anoctamin 1, calcium activated chloride channel 2.54577
MYLK3 myosin light chain kinase 3 2.54288
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.41931
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.2457
ZBBX zinc finger, B-box domain containing 2.17189
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.1262
PRR15L proline rich 15-like 2.12477
ZNF589 zinc finger protein 589 2.1224
TTC26 tetratricopeptide repeat domain 26 2.10286
TPM3 tropomyosin 3 2.09717
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.09
CYCS cytochrome c, somatic 2.05236
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 2.00693
CFAP46 cilia and flagella associated protein 46 2.00282

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.0754
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.72493
VAT1 vesicle amine transport 1 -4.69546
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -4.43776
CD320 CD320 molecule -4.27813
CCNB2 cyclin B2 -3.62471
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.41167
CTSD cathepsin D -3.22049
SNX11 sorting nexin 11 -3.02899
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.85442
HMG20B high mobility group 20B -2.84324
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.70728
ZBTB5 zinc finger and BTB domain containing 5 -2.61435
CRELD2 cysteine-rich with EGF-like domains 2 -2.599
FBXL12 F-box and leucine-rich repeat protein 12 -2.58468
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.33709
STAT1 signal transducer and activator of transcription 1, 91kDa -2.23096
SCAND1 SCAN domain containing 1 -2.22723
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.14877