CRCGN013_HEPG2_24H:E05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description d-mannitol 2.51 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

29 genes differentially expressed following the CRCGN013_HEPG2_24H:E05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 6.42645
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 4.43546
CYCS cytochrome c, somatic 4.41402
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.7036
CBR3 carbonyl reductase 3 3.53409
C2CD2 C2 calcium-dependent domain containing 2 3.20551
VAV3 vav 3 guanine nucleotide exchange factor 2.92685
SSBP2 single-stranded DNA binding protein 2 2.92484
PLSCR3 phospholipid scramblase 3 2.70812
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.63752
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.57649
MYLK myosin light chain kinase 2.32793
DYNLT3 dynein, light chain, Tctex-type 3 2.24837
CDPF1 cysteine-rich, DPF motif domain containing 1 2.14707
CCL2 chemokine (C-C motif) ligand 2 2.14179
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.07817
ZIC1 Zic family member 1 2.05944

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -4.86395
GDF15 growth differentiation factor 15 -4.3639
VDAC1 voltage-dependent anion channel 1 -3.92966
VAT1 vesicle amine transport 1 -3.87714
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.74881
ZNF586 zinc finger protein 586 -3.36276
LDHD lactate dehydrogenase D -2.80791
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.65583
MAPK13 mitogen-activated protein kinase 13 -2.52426
NRIP1 nuclear receptor interacting protein 1 -2.37499
GNAS GNAS complex locus -2.24338
EGF epidermal growth factor -2.16359