CRCGN013_HEPG2_24H:E09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ethylene thiourea 9.85 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN013_HEPG2_24H:E09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 3.8342
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.7342
RPL39L ribosomal protein L39-like 3.59907
RPP38 ribonuclease P/MRP 38kDa subunit 3.549
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.4551
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.43803
CHMP6 charged multivesicular body protein 6 3.40577
ANO1 anoctamin 1, calcium activated chloride channel 3.33333
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.3111
UBQLN2 ubiquilin 2 3.12013
GSTZ1 glutathione S-transferase zeta 1 3.07147
MOK MOK protein kinase 3.05903
EPHA3 EPH receptor A3 3.03006
PRKCQ protein kinase C, theta 2.81742
SNAP25 synaptosomal-associated protein, 25kDa 2.5991
SSBP2 single-stranded DNA binding protein 2 2.44683
USP6NL USP6 N-terminal like 2.43627
PPARG peroxisome proliferator-activated receptor gamma 2.3172
HLA-DMA major histocompatibility complex, class II, DM alpha 2.30463
GPER1 G protein-coupled estrogen receptor 1 2.28202
CGRRF1 cell growth regulator with ring finger domain 1 2.22843
KLHL21 kelch-like family member 21 2.12063
LCN2 lipocalin 2 2.11993
CCNH cyclin H 2.09203
KIF20A kinesin family member 20A 2.06383
GHR growth hormone receptor 2.0291
PRR15L proline rich 15-like 2.0043

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.62533
ENOPH1 enolase-phosphatase 1 -3.95883
DNM1L dynamin 1-like -3.69987
ZNF586 zinc finger protein 586 -3.39103
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.2146
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.95703
BLCAP bladder cancer associated protein -2.85217
FGFR4 fibroblast growth factor receptor 4 -2.5796
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.35393
ZMIZ1 zinc finger, MIZ-type containing 1 -2.35303
ICAM3 intercellular adhesion molecule 3 -2.34273
RFC2 replication factor C (activator 1) 2, 40kDa -2.24522
GNAS GNAS complex locus -2.22617
NGRN neugrin, neurite outgrowth associated -2.19927
EIF5 eukaryotic translation initiation factor 5 -2.13908
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.09163