CRCGN013_HEPG2_24H:E10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ethylene thiourea 4.92 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN013_HEPG2_24H:E10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.87153
EVL Enah/Vasp-like 4.57917
HLA-DMA major histocompatibility complex, class II, DM alpha 4.03993
ADRB2 adrenoceptor beta 2, surface 3.69037
SNAP25 synaptosomal-associated protein, 25kDa 3.48845
UBQLN2 ubiquilin 2 3.4157
STXBP2 syntaxin binding protein 2 3.36867
DENND2D DENN/MADD domain containing 2D 3.36803
PPARG peroxisome proliferator-activated receptor gamma 3.30783
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.24767
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.23687
E2F2 E2F transcription factor 2 3.18437
GRWD1 glutamate-rich WD repeat containing 1 3.1232
BACE2 beta-site APP-cleaving enzyme 2 3.0
AMDHD2 amidohydrolase domain containing 2 2.9952
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.99273
GSTZ1 glutathione S-transferase zeta 1 2.95113
CCL2 chemokine (C-C motif) ligand 2 2.65493
ANO1 anoctamin 1, calcium activated chloride channel 2.62983
PLSCR1 phospholipid scramblase 1 2.6108
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.50943
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.48583
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.47797
NFIL3 nuclear factor, interleukin 3 regulated 2.41647
ALDOC aldolase C, fructose-bisphosphate 2.38707
TLR4 toll-like receptor 4 2.32073
PRKCH protein kinase C, eta 2.15453
TGIF1 TGFB-induced factor homeobox 1 2.14067
GARRE1 granule associated Rac and RHOG effector 1 2.1156
NOSIP nitric oxide synthase interacting protein 2.1038
EPHA3 EPH receptor A3 2.10261
MYLK myosin light chain kinase 2.0609
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.06
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.0361
SSBP2 single-stranded DNA binding protein 2 2.0185

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.44183
OXA1L oxidase (cytochrome c) assembly 1-like -5.5726
UBE3C ubiquitin protein ligase E3C -5.2729
CCNB2 cyclin B2 -4.427
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.8251
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.6369
LDHD lactate dehydrogenase D -3.49107
MRPS2 mitochondrial ribosomal protein S2 -3.20223
TRIB3 tribbles pseudokinase 3 -2.98377
NRIP1 nuclear receptor interacting protein 1 -2.94138
FHL2 four and a half LIM domains 2 -2.84367
RPIA ribose 5-phosphate isomerase A -2.68207
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.64407
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.6164
NT5DC2 5'-nucleotidase domain containing 2 -2.6049
LOC124907782 dual specificity protein phosphatase 22 -2.55477
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.54297
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.43497
NVL nuclear VCP-like -2.23783
CDPF1 cysteine-rich, DPF motif domain containing 1 -2.22123
GNAS GNAS complex locus -2.1984
MVP major vault protein -2.19183
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.14058
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.1153