CRCGN013_HEPG2_24H:E11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ethylene thiourea 2.46 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN013_HEPG2_24H:E11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 5.3717
ALDOC aldolase C, fructose-bisphosphate 4.99775
CHN1 chimerin 1 4.15238
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.06672
PEX11A peroxisomal biogenesis factor 11 alpha 4.06328
FCHO1 FCH domain only 1 3.7025
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.65038
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 3.46211
EGF epidermal growth factor 3.22545
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 3.10437
PLSCR1 phospholipid scramblase 1 3.08702
SSBP2 single-stranded DNA binding protein 2 3.01511
PROS1 protein S (alpha) 2.97534
KIFBP kinesin family binding protein 2.94917
GTPBP8 GTP-binding protein 8 (putative) 2.48221
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 2.22181
LOC102724560 cystathionine beta-synthase 2.19022
XAF1 XIAP associated factor 1 2.10887
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 2.06128

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -7.35681
CCNB2 cyclin B2 -7.16664
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.23627
PLK1 polo-like kinase 1 -5.10488
NGRN neugrin, neurite outgrowth associated -4.99854
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.42606
LDHD lactate dehydrogenase D -4.39175
MAPK13 mitogen-activated protein kinase 13 -3.79145
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.76472
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.71742
THAP11 THAP domain containing 11 -3.45218
KDM3A lysine (K)-specific demethylase 3A -3.4406
TLR4 toll-like receptor 4 -3.2559
WDR7 WD repeat domain 7 -3.17961
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.99311
HAT1 histone acetyltransferase 1 -2.98837
TNIP1 TNFAIP3 interacting protein 1 -2.72547
S100A4 S100 calcium binding protein A4 -2.72543
RGS2 regulator of G-protein signaling 2 -2.69666
GNAS GNAS complex locus -2.64211
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 -2.63406
RNPS1 RNA binding protein S1, serine-rich domain -2.63292
HMG20B high mobility group 20B -2.53319
FRS3 fibroblast growth factor receptor substrate 3 -2.52838
LOC124907782 dual specificity protein phosphatase 22 -2.39121
NT5M 5',3'-nucleotidase, mitochondrial -2.37837
SNX11 sorting nexin 11 -2.34644
KRT14 keratin 14, type I -2.32075
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) -2.30852
NRIP1 nuclear receptor interacting protein 1 -2.26752
KRT17 keratin 17, type I -2.23296
PCNA proliferating cell nuclear antigen -2.2207
MTSS1 metastasis suppressor 1 -2.19619
TOR1A torsin family 1, member A (torsin A) -2.11428
MCTP2 multiple C2 domains, transmembrane 2 -2.08226
S100A6 S100 calcium binding protein A6 -2.02936
INSIG1 insulin induced gene 1 -2.02068