CRCGN013_HEPG2_24H:E15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methyl (z)-2-(dimethylamino)-n-((methylcarbamoyl)oxy)-2-oxoethanimidothioate 5.02 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN013_HEPG2_24H:E15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPER1 G protein-coupled estrogen receptor 1 6.1802
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.6343
RPL39L ribosomal protein L39-like 5.43392
MCOLN1 mucolipin 1 5.25084
E2F2 E2F transcription factor 2 5.16574
C2CD2 C2 calcium-dependent domain containing 2 5.16066
PPARG peroxisome proliferator-activated receptor gamma 5.02824
ADGRE5 adhesion G protein-coupled receptor E5 4.93986
CCL2 chemokine (C-C motif) ligand 2 4.82969
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.67655
EPHA3 EPH receptor A3 4.41296
CHN1 chimerin 1 3.98285
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 3.88303
PRR15L proline rich 15-like 3.81907
HLA-DMA major histocompatibility complex, class II, DM alpha 3.24536
NOSIP nitric oxide synthase interacting protein 3.22559
LOC122526780 uncharacterized LOC122526780 3.154
CIAO3 cytosolic iron-sulfur assembly component 3 2.89123
PEX11A peroxisomal biogenesis factor 11 alpha 2.87149
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.77887
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.75578
GSTZ1 glutathione S-transferase zeta 1 2.73138
TIAM1 T-cell lymphoma invasion and metastasis 1 2.70487
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.60189
HLA-DRA major histocompatibility complex, class II, DR alpha 2.5999
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.54305
LPAR2 lysophosphatidic acid receptor 2 2.4924
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.4629
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.22091
SYNE2 spectrin repeat containing, nuclear envelope 2 2.17015
RRAGA Ras-related GTP binding A 2.04912
UBFD1 ubiquitin family domain containing 1 2.02444
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) 2.00739
CEP112 centrosomal protein 112kDa 2.00076

decreased expression

Symbol Name Standardized Value
UBE3C ubiquitin protein ligase E3C -4.73788
DNM1L dynamin 1-like -4.70793
PECR peroxisomal trans-2-enoyl-CoA reductase -4.18827
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.98905
OXA1L oxidase (cytochrome c) assembly 1-like -3.96025
SLC35F2 solute carrier family 35, member F2 -3.76535
LDHD lactate dehydrogenase D -3.40057
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.35573
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -3.30856
SNX11 sorting nexin 11 -3.25714
ZMIZ1 zinc finger, MIZ-type containing 1 -3.01451
DERA deoxyribose-phosphate aldolase (putative) -2.90283
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.81349
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.78766
TM9SF3 transmembrane 9 superfamily member 3 -2.4584
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.3353
CCNB2 cyclin B2 -2.33293
STIM1 stromal interaction molecule 1 -2.19535
TLCD3A TLC domain containing 3A -2.16157
NRIP1 nuclear receptor interacting protein 1 -2.1318
MAPK13 mitogen-activated protein kinase 13 -2.07975
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -2.04077
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.0284