CRCGN013_HEPG2_24H:E20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (e)-n-(4-(2-(3-methyl-6-oxocyclohexa-2,4-dien-1-ylidene)hydrazinyl)phenyl)acetamide 10.77 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN013_HEPG2_24H:E20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STIMATE STIM activating enhancer 7.79972
LCN2 lipocalin 2 6.4428
GPATCH8 G patch domain containing 8 5.19022
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 4.58471
STK10 serine/threonine kinase 10 4.55569
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.16301
SKIC2 SKI2 subunit of superkiller complex 3.85578
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.54656
NOTCH1 notch 1 3.4729
ADGRE5 adhesion G protein-coupled receptor E5 3.44961
UGDH UDP-glucose 6-dehydrogenase 3.3103
TBP TATA box binding protein 3.21761
TXNRD1 thioredoxin reductase 1 3.18902
PFKL phosphofructokinase, liver 3.12303
HEBP1 heme binding protein 1 3.03633
MCUR1 mitochondrial calcium uniporter regulator 1 2.85213
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.70405
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.59321
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.55915
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.5338
PLSCR3 phospholipid scramblase 3 2.42253
ZBTB24 zinc finger and BTB domain containing 24 2.4083
PRR7 proline rich 7 (synaptic) 2.2934
KLHL9 kelch-like family member 9 2.25486
SQSTM1 sequestosome 1 2.24989
TRIM16 tripartite motif containing 16 2.21235
DBR1 debranching RNA lariats 1 2.20271
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.20087
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 2.18675
DACT1 dishevelled-binding antagonist of beta-catenin 1 2.15618
SSBP2 single-stranded DNA binding protein 2 2.1116
NEIL3 nei endonuclease VIII-like 3 (E. coli) 2.09856
HLA-DRA major histocompatibility complex, class II, DR alpha 2.08063
SAP25 Sin3A-associated protein, 25kDa 2.04008
LPAR2 lysophosphatidic acid receptor 2 2.03954
DTD1 D-tyrosyl-tRNA deacylase 1 2.02524
ABHD4 abhydrolase domain containing 4 2.02425

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -7.44323
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -4.48523
CDC20 cell division cycle 20 -4.30362
CCDC86 coiled-coil domain containing 86 -4.16371
CCNB1 cyclin B1 -4.11809
CCNB2 cyclin B2 -3.99462
PEG10 paternally expressed 10 -3.96417
DUSP6 dual specificity phosphatase 6 -3.91449
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.81111
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.80548
TLCD3A TLC domain containing 3A -3.72384
ARID5B AT rich interactive domain 5B (MRF1-like) -3.66518
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.44987
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.41504
EGF epidermal growth factor -3.25025
EIF5 eukaryotic translation initiation factor 5 -3.22473
DERA deoxyribose-phosphate aldolase (putative) -3.14406
OXA1L oxidase (cytochrome c) assembly 1-like -2.92204
TES testin LIM domain protein -2.45734
PRPF4 pre-mRNA processing factor 4 -2.34983
NRIP1 nuclear receptor interacting protein 1 -2.19487
CNIH3 cornichon family AMPA receptor auxiliary protein 3 -2.18564
GOLT1B golgi transport 1B -2.17973
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 -2.16942