CRCGN013_HEPG2_24H:E21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (e)-n-(4-(2-(3-methyl-6-oxocyclohexa-2,4-dien-1-ylidene)hydrazinyl)phenyl)acetamide 5.38 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN013_HEPG2_24H:E21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCR4 chemokine (C-X-C motif) receptor 4 5.12869
CCDC85B coiled-coil domain containing 85B 4.89376
STIMATE STIM activating enhancer 4.49093
LCN2 lipocalin 2 4.19931
E2F2 E2F transcription factor 2 4.10756
ADRB2 adrenoceptor beta 2, surface 3.87436
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.39928
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.35008
GPER1 G protein-coupled estrogen receptor 1 3.27234
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.25973
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.25968
PPARG peroxisome proliferator-activated receptor gamma 3.25366
RXYLT1 ribitol xylosyltransferase 1 3.15569
ADAT1 adenosine deaminase, tRNA-specific 1 2.99094
VAV3 vav 3 guanine nucleotide exchange factor 2.97921
PRR15L proline rich 15-like 2.80224
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.65858
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.64679
TIAM1 T-cell lymphoma invasion and metastasis 1 2.57748
TXNRD1 thioredoxin reductase 1 2.53312
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.3881
UGDH UDP-glucose 6-dehydrogenase 2.33866
CCNH cyclin H 2.26063
GPATCH8 G patch domain containing 8 2.23775
ABHD4 abhydrolase domain containing 4 2.18068
PLS1 plastin 1 2.14285
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 2.11242
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.03502
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.03127
CHN1 chimerin 1 2.01331

decreased expression

Symbol Name Standardized Value
AURKB aurora kinase B -4.77306
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.19931
CHMP4B charged multivesicular body protein 4B -3.88511
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -3.67409
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.56901
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -3.55775
WASHC4 WASH complex subunit 4 -3.5028
DERA deoxyribose-phosphate aldolase (putative) -3.38311
ANKRD10 ankyrin repeat domain 10 -3.10658
VDAC1 voltage-dependent anion channel 1 -3.04509
RFC2 replication factor C (activator 1) 2, 40kDa -3.00696
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.64076
GNAS GNAS complex locus -2.45105
PLK1 polo-like kinase 1 -2.31541
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.26109