CRCGN013_HEPG2_24H:F06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ethyl alcohol 1.32 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN013_HEPG2_24H:F06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 8.75331
HLA-DMA major histocompatibility complex, class II, DM alpha 4.06697
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.78064
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.56631
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 3.01043
WASF3 WAS protein family, member 3 2.62516
NOSIP nitric oxide synthase interacting protein 2.58883
RRAGA Ras-related GTP binding A 2.34975
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) 2.29567
SH3D19 SH3 domain containing 19 2.26455
TECR trans-2,3-enoyl-CoA reductase 2.25192
CHEK2 checkpoint kinase 2 2.24481
SPRY2 sprouty homolog 2 (Drosophila) 2.07207
TBP TATA box binding protein 2.01982
POU5F1 POU class 5 homeobox 1 2.00276

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -7.46183
NT5DC2 5'-nucleotidase domain containing 2 -5.43688
CD320 CD320 molecule -5.12166
ANKRD10 ankyrin repeat domain 10 -4.9877
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.68548
COG4 component of oligomeric golgi complex 4 -4.61901
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.48262
DNM1L dynamin 1-like -4.34342
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.66717
TXNDC9 thioredoxin domain containing 9 -2.9736
HMG20B high mobility group 20B -2.91283
CDC20 cell division cycle 20 -2.89803
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.89795
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.72735
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.61276
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.50678
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.48549
SNX11 sorting nexin 11 -2.45382
EDDM3B epididymal protein 3B -2.42928
PRKD3 protein kinase D3 -2.20516
ICAM3 intercellular adhesion molecule 3 -2.18386
ADAM7 ADAM metallopeptidase domain 7 -2.13528
CYTH3 cytohesin 3 -2.10962
MDM4 MDM4, p53 regulator -2.07253
RIPPLY2-CYB5R4 RIPPLY2-CYB5R4 readthrough -2.07164
PACS1 phosphofurin acidic cluster sorting protein 1 -2.06185
ELSPBP1 epididymal sperm binding protein 1 -2.05408
CRISP1 cysteine-rich secretory protein 1 -2.04242
RASL10A RAS-like, family 10, member A -2.03267
EDDM3A epididymal protein 3A -2.0069