CRCGN013_HEPG2_24H:F11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

49 genes differentially expressed following the CRCGN013_HEPG2_24H:F11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHN1 chimerin 1 7.84075
RAB11FIP1 RAB11 family interacting protein 1 (class I) 5.99789
TBC1D10C TBC1 domain family, member 10C 5.4149
MAP7 microtubule-associated protein 7 5.27108
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 4.62074
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.25779
TREM1 triggering receptor expressed on myeloid cells 1 4.20436
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.91702
DYNLT3 dynein, light chain, Tctex-type 3 3.72216
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.59211
RRAGA Ras-related GTP binding A 3.56089
ATP11B ATPase, class VI, type 11B 3.4719
FZD7 frizzled class receptor 7 3.46661
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.36371
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.2703
BAX BCL2-associated X protein 3.21888
MCUR1 mitochondrial calcium uniporter regulator 1 3.19797
RGPD2 RANBP2-like and GRIP domain containing 2 2.72712
PDLIM1 PDZ and LIM domain 1 2.71993
CNPY3 canopy FGF signaling regulator 3 2.62351
BTK Bruton agammaglobulinemia tyrosine kinase 2.2899
MCM3 minichromosome maintenance complex component 3 2.21941
ADAT1 adenosine deaminase, tRNA-specific 1 2.14693
TBCC tubulin folding cofactor C 2.1027
NOSIP nitric oxide synthase interacting protein 2.09826
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.01943

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.21766
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.13564
ITFG1 integrin alpha FG-GAP repeat containing 1 -5.12321
CD320 CD320 molecule -4.93406
BLCAP bladder cancer associated protein -4.89932
CHMP4B charged multivesicular body protein 4B -4.49781
GTPBP8 GTP-binding protein 8 (putative) -4.25345
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.1444
MEST mesoderm specific transcript -4.05602
CCNB2 cyclin B2 -4.04419
MAPK13 mitogen-activated protein kinase 13 -3.70347
GNAS GNAS complex locus -3.26194
RAI14 retinoic acid induced 14 -2.73262
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.61636
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.61089
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.51353
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.41615
OXA1L oxidase (cytochrome c) assembly 1-like -2.36998
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.29429
RGS20 regulator of G-protein signaling 20 -2.23783
ZMIZ1 zinc finger, MIZ-type containing 1 -2.12638
TXNRD1 thioredoxin reductase 1 -2.09879
CHIC2 cysteine-rich hydrophobic domain 2 -2.08743