CRCGN013_HEPG2_24H:F13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (1s,2s)-2-(1-methyl-2-oxohydrazino)-1-phenyl-1-propanol 19.98 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

36 genes differentially expressed following the CRCGN013_HEPG2_24H:F13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPER1 G protein-coupled estrogen receptor 1 4.60971
PPARG peroxisome proliferator-activated receptor gamma 4.43453
GATA3 GATA binding protein 3 4.0034
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.99462
NOSIP nitric oxide synthase interacting protein 3.58806
CYCS cytochrome c, somatic 2.92755
SFTPB surfactant protein B 2.8983
CDC45 cell division cycle 45 2.63213
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.3699
HSPA1A heat shock 70kDa protein 1A 2.35677
SSBP2 single-stranded DNA binding protein 2 2.34717
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.28888
STIMATE STIM activating enhancer 2.12383
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.05157
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 2.04301
PRR15L proline rich 15-like 2.02086

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.69471
NUP85 nucleoporin 85kDa -4.47063
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.46312
LDHD lactate dehydrogenase D -4.29424
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.21756
CD58 CD58 molecule -2.72638
GOLT1B golgi transport 1B -2.58597
WASHC4 WASH complex subunit 4 -2.42372
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.40464
MRPS7 mitochondrial ribosomal protein S7 -2.32115
TOMM34 translocase of outer mitochondrial membrane 34 -2.26613
KCTD2 potassium channel tetramerization domain containing 2 -2.22481
HTRA1 HtrA serine peptidase 1 -2.19347
SMIM5 small integral membrane protein 5 -2.11167
MAP7 microtubule-associated protein 7 -2.10678
RAI14 retinoic acid induced 14 -2.0816
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.07784
MAPK13 mitogen-activated protein kinase 13 -2.0601
DSG2 desmoglein 2 -2.03925
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.03711