CRCGN013_HEPG2_24H:F16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (1s,2s)-2-(1-methyl-2-oxohydrazino)-1-phenyl-1-propanol 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

47 genes differentially expressed following the CRCGN013_HEPG2_24H:F16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPER1 G protein-coupled estrogen receptor 1 6.29811
E2F2 E2F transcription factor 2 5.67439
HLA-DRA major histocompatibility complex, class II, DR alpha 5.19162
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.7974
HLA-DMA major histocompatibility complex, class II, DM alpha 4.10618
CARMIL1 capping protein regulator and myosin 1 linker 1 3.87042
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.85335
SNAP25 synaptosomal-associated protein, 25kDa 3.64134
MAP7 microtubule-associated protein 7 3.27317
PEX11A peroxisomal biogenesis factor 11 alpha 3.02344
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.87358
CYCS cytochrome c, somatic 2.79937
PLSCR3 phospholipid scramblase 3 2.77015
CD40 CD40 molecule, TNF receptor superfamily member 5 2.59078
VGLL4 vestigial-like family member 4 2.575
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 2.4473
HSPA1A heat shock 70kDa protein 1A 2.43403
JADE2 jade family PHD finger 2 2.37282
CCDC85B coiled-coil domain containing 85B 2.34582
PRR7 proline rich 7 (synaptic) 2.27245
LCN2 lipocalin 2 2.24483
CRTAP cartilage associated protein 2.17792
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 2.16825
CXCL2 chemokine (C-X-C motif) ligand 2 2.14823
TMEM14A transmembrane protein 14A 2.12834
SQOR sulfide quinone oxidoreductase 2.1237
CHN1 chimerin 1 2.05942
MCUR1 mitochondrial calcium uniporter regulator 1 2.0536
MELK maternal embryonic leucine zipper kinase 2.02251
RBKS ribokinase 2.01403

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -6.26739
VAT1 vesicle amine transport 1 -6.13794
GNAS GNAS complex locus -4.34291
OXA1L oxidase (cytochrome c) assembly 1-like -4.32011
KDM3A lysine (K)-specific demethylase 3A -3.81134
NCK1 NCK adaptor protein 1 -3.54636
ADI1 acireductone dioxygenase 1 -3.39566
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -3.18275
ZMIZ1 zinc finger, MIZ-type containing 1 -3.05971
FGFR4 fibroblast growth factor receptor 4 -2.58661
RFC2 replication factor C (activator 1) 2, 40kDa -2.52997
PGM1 phosphoglucomutase 1 -2.33915
ANKRD10 ankyrin repeat domain 10 -2.33722
LDHD lactate dehydrogenase D -2.26282
ZDHHC6 zinc finger, DHHC-type containing 6 -2.06589
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.05693
TMEM109 transmembrane protein 109 -2.02286