CRCGN013_HEPG2_24H:F17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (1s,2s)-2-(1-methyl-2-oxohydrazino)-1-phenyl-1-propanol 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

37 genes differentially expressed following the CRCGN013_HEPG2_24H:F17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHN1 chimerin 1 3.74303
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.74197
GPATCH8 G patch domain containing 8 3.47752
RAB11FIP1 RAB11 family interacting protein 1 (class I) 3.36233
LYN LYN proto-oncogene, Src family tyrosine kinase 3.3536
C2CD2 C2 calcium-dependent domain containing 2 3.20553
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.2052
LCN2 lipocalin 2 3.17797
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.1415
ADGRE5 adhesion G protein-coupled receptor E5 3.1011
CCDC85B coiled-coil domain containing 85B 2.9259
E2F2 E2F transcription factor 2 2.90047
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.8666
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.7781
NOTCH1 notch 1 2.7171
TIAM1 T-cell lymphoma invasion and metastasis 1 2.40517
TBP TATA box binding protein 2.24737
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.24597
SSBP2 single-stranded DNA binding protein 2 2.15907
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.04687
PLS1 plastin 1 2.03497

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.47797
CCNB2 cyclin B2 -4.69813
GNAS GNAS complex locus -4.68431
CDC25B cell division cycle 25B -4.03457
ANKRD10 ankyrin repeat domain 10 -3.4839
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.14513
MAP7 microtubule-associated protein 7 -2.85349
SLC35F2 solute carrier family 35, member F2 -2.69047
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.56823
TRIB3 tribbles pseudokinase 3 -2.5179
ADI1 acireductone dioxygenase 1 -2.30227
PCNA proliferating cell nuclear antigen -2.27317
MAPK13 mitogen-activated protein kinase 13 -2.26665
CCNB1 cyclin B1 -2.2205
LRRC41 leucine rich repeat containing 41 -2.1661
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.0881