CRCGN013_HEPG2_24H:F19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4,6-trimethylaniline 20.07 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

52 genes differentially expressed following the CRCGN013_HEPG2_24H:F19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 10.0
MAP7 microtubule-associated protein 7 4.25796
NOSIP nitric oxide synthase interacting protein 4.08388
E2F2 E2F transcription factor 2 3.38275
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.38151
SQOR sulfide quinone oxidoreductase 3.37874
CCL2 chemokine (C-C motif) ligand 2 3.32839
EPHA3 EPH receptor A3 3.32095
STIMATE STIM activating enhancer 3.30772
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 3.17943
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.02485
SNAP25 synaptosomal-associated protein, 25kDa 3.0187
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.97509
GSTZ1 glutathione S-transferase zeta 1 2.93612
TBP TATA box binding protein 2.72919
ABHD6 abhydrolase domain containing 6 2.72883
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.70948
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.68849
BZW2 basic leucine zipper and W2 domains 2 2.60969
STK10 serine/threonine kinase 10 2.5793
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.54289
CDK19 cyclin-dependent kinase 19 2.48233
CCNF cyclin F 2.41599
CEMIP2 cell migration inducing hyaluronidase 2 2.28962
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.27195
MAST2 microtubule associated serine/threonine kinase 2 2.20531
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.14652
RRAGA Ras-related GTP binding A 2.12488
ENO3 enolase 3 (beta, muscle) 2.08689
PITX2 paired-like homeodomain 2 2.02148

decreased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 -6.39392
PCNA proliferating cell nuclear antigen -5.15481
CCNB2 cyclin B2 -4.86445
NT5DC2 5'-nucleotidase domain containing 2 -3.68125
ACOT9 acyl-CoA thioesterase 9 -3.51737
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -3.46703
CCNB1 cyclin B1 -3.29805
OXA1L oxidase (cytochrome c) assembly 1-like -3.27771
UGDH UDP-glucose 6-dehydrogenase -3.24137
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.20701
LDHD lactate dehydrogenase D -3.09425
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.04349
CHMP4B charged multivesicular body protein 4B -2.97662
TMCO1 transmembrane and coiled-coil domains 1 -2.90819
RGS2 regulator of G-protein signaling 2 -2.72379
MAPK13 mitogen-activated protein kinase 13 -2.47303
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.3886
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.36167
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.2531
GNAS GNAS complex locus -2.23817
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.11032
ASS1 argininosuccinate synthase 1 -2.1009