CRCGN013_HEPG2_24H:F20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4,6-trimethylaniline 10.04 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

62 genes differentially expressed following the CRCGN013_HEPG2_24H:F20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 7.37066
CHMP6 charged multivesicular body protein 6 5.31535
LCN2 lipocalin 2 5.00739
MYLK myosin light chain kinase 4.98747
GSTZ1 glutathione S-transferase zeta 1 4.90514
SYNE2 spectrin repeat containing, nuclear envelope 2 4.88909
E2F2 E2F transcription factor 2 4.65577
JADE2 jade family PHD finger 2 4.65402
CBR3 carbonyl reductase 3 4.37455
NOTCH1 notch 1 4.33776
IDE insulin-degrading enzyme 4.04785
SNAP25 synaptosomal-associated protein, 25kDa 3.98052
CXCR4 chemokine (C-X-C motif) receptor 4 3.60637
CEP57 centrosomal protein 57kDa 3.51577
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 3.37508
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.36755
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.88031
PRR7 proline rich 7 (synaptic) 2.83847
PRR15L proline rich 15-like 2.75696
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 2.73475
CYCS cytochrome c, somatic 2.70685
EDN1 endothelin 1 2.66989
HYOU1 hypoxia up-regulated 1 2.54792
TIAM1 T-cell lymphoma invasion and metastasis 1 2.50774
CHN1 chimerin 1 2.48509
GRWD1 glutamate-rich WD repeat containing 1 2.39768
MAP7 microtubule-associated protein 7 2.39597
SFTPB surfactant protein B 2.33718
GPATCH8 G patch domain containing 8 2.33011
PBX3 pre-B-cell leukemia homeobox 3 2.29112
ZWILCH zwilch kinetochore protein 2.24228
BCAS2 breast carcinoma amplified sequence 2 2.21802
EPHA1 EPH receptor A1 2.1666
RAB25 RAB25, member RAS oncogene family 2.14516
LTBP1 latent transforming growth factor beta binding protein 1 2.14155
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 2.13154
FPGS folylpolyglutamate synthase 2.08353
OARD1 O-acyl-ADP-ribose deacylase 1 2.05743

decreased expression

Symbol Name Standardized Value
CD320 CD320 molecule -7.24177
KDM3A lysine (K)-specific demethylase 3A -5.34431
DERA deoxyribose-phosphate aldolase (putative) -5.319
PCNA proliferating cell nuclear antigen -4.71853
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.6384
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.27185
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.24156
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.23117
PTPRK protein tyrosine phosphatase, receptor type, K -4.0136
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.82768
TLCD3A TLC domain containing 3A -3.68238
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.38774
OXA1L oxidase (cytochrome c) assembly 1-like -3.30246
GNAS GNAS complex locus -3.29452
MTFR1 mitochondrial fission regulator 1 -3.06673
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.03123
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.01548
TM9SF3 transmembrane 9 superfamily member 3 -2.917
TXNDC9 thioredoxin domain containing 9 -2.78845
DCK deoxycytidine kinase -2.33046
NECAB3 N-terminal EF-hand calcium binding protein 3 -2.19373
TMEM131 transmembrane protein 131 -2.11859
TGFB3 transforming growth factor, beta 3 -2.05885
ZNF557 zinc finger protein 557 -2.03042