CRCGN013_HEPG2_24H:F21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4,6-trimethylaniline 5.02 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

58 genes differentially expressed following the CRCGN013_HEPG2_24H:F21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHMP6 charged multivesicular body protein 6 5.22712
CARMIL1 capping protein regulator and myosin 1 linker 1 4.91333
HLA-DMA major histocompatibility complex, class II, DM alpha 4.89108
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.72207
MOK MOK protein kinase 4.50838
ADRB2 adrenoceptor beta 2, surface 4.50023
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 4.49504
LCN2 lipocalin 2 4.35415
PPARG peroxisome proliferator-activated receptor gamma 4.27307
STIMATE STIM activating enhancer 4.15935
NOTCH1 notch 1 4.10913
TIAM1 T-cell lymphoma invasion and metastasis 1 4.04149
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.88105
CCL2 chemokine (C-C motif) ligand 2 3.86463
CBR3 carbonyl reductase 3 3.81196
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 3.4396
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.40606
CYB561 cytochrome b561 3.28752
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.21347
GPER1 G protein-coupled estrogen receptor 1 3.06253
PRR15L proline rich 15-like 2.83091
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.72846
MCUR1 mitochondrial calcium uniporter regulator 1 2.51224
NUTF2 nuclear transport factor 2 2.47358
UFM1 ubiquitin-fold modifier 1 2.3591
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.35304
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 2.35165
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.34311
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.31558
NGRN neugrin, neurite outgrowth associated 2.3075
PCOLCE2 procollagen C-endopeptidase enhancer 2 2.17319
KLHL9 kelch-like family member 9 2.15226
JADE2 jade family PHD finger 2 2.14401
PMM2 phosphomannomutase 2 2.11288
SDAD1 SDA1 domain containing 1 2.08816
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.05039
ZNF589 zinc finger protein 589 2.01059
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.00998

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -5.8975
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.41433
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.15686
AURKB aurora kinase B -4.38182
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.02478
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.768
TLCD3A TLC domain containing 3A -3.75426
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.6259
TM9SF3 transmembrane 9 superfamily member 3 -3.49656
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.23208
MTA1 metastasis associated 1 -2.73474
TXNDC9 thioredoxin domain containing 9 -2.68212
TES testin LIM domain protein -2.53172
TLR4 toll-like receptor 4 -2.47902
EXT1 exostosin glycosyltransferase 1 -2.44101
CCNB1 cyclin B1 -2.39008
PRMT3 protein arginine methyltransferase 3 -2.34576
NR2C2 nuclear receptor subfamily 2, group C, member 2 -2.28533
EBNA1BP2 EBNA1 binding protein 2 -2.1687
PHKG2 phosphorylase kinase, gamma 2 (testis) -2.08135