CRCGN013_HEPG2_24H:F24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4,6-trimethylaniline 0.63 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

51 genes differentially expressed following the CRCGN013_HEPG2_24H:F24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 6.63701
BZW2 basic leucine zipper and W2 domains 2 6.20161
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 5.13792
RPP38 ribonuclease P/MRP 38kDa subunit 4.6738
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 4.03594
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.82333
FAIM Fas apoptotic inhibitory molecule 3.52649
E2F2 E2F transcription factor 2 3.26829
RAB11FIP1 RAB11 family interacting protein 1 (class I) 3.21319
TMEM50A transmembrane protein 50A 3.14725
LCN2 lipocalin 2 2.99563
GSTZ1 glutathione S-transferase zeta 1 2.92855
PRDX4 peroxiredoxin 4 2.66637
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.61818
EVL Enah/Vasp-like 2.4965
WASF3 WAS protein family, member 3 2.40399
GARRE1 granule associated Rac and RHOG effector 1 2.36729
LRP10 low density lipoprotein receptor-related protein 10 2.25064
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.17074
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.07741
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 2.06016
TIAM1 T-cell lymphoma invasion and metastasis 1 2.03432

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.6772
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.4316
OXA1L oxidase (cytochrome c) assembly 1-like -4.98866
SLC35F2 solute carrier family 35, member F2 -4.93706
COG2 component of oligomeric golgi complex 2 -4.90667
UGDH UDP-glucose 6-dehydrogenase -4.8963
VAT1 vesicle amine transport 1 -4.7824
NT5DC2 5'-nucleotidase domain containing 2 -4.04047
TUBB6 tubulin, beta 6 class V -3.97478
GNAS GNAS complex locus -3.70997
DNM1L dynamin 1-like -3.68453
HMG20B high mobility group 20B -3.39228
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -3.16411
TXNDC9 thioredoxin domain containing 9 -2.99338
EGF epidermal growth factor -2.58956
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.5871
ILK integrin-linked kinase -2.56609
CCP110 centriolar coiled coil protein 110kDa -2.50751
MEOX2 mesenchyme homeobox 2 -2.3919
SUOX sulfite oxidase -2.16809
KDM3A lysine (K)-specific demethylase 3A -2.16611
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.15665
SNX24 sorting nexin 24 -2.14699
PTPN6 protein tyrosine phosphatase, non-receptor type 6 -2.14553
ITGB1BP1 integrin beta 1 binding protein 1 -2.11662
USP39 ubiquitin specific peptidase 39 -2.0458
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A -2.01898
EPM2AIP1 EPM2A (laforin) interacting protein 1 -2.01656
THSD7A thrombospondin, type I, domain containing 7A -2.01428