CRCGN013_HEPG2_24H:G02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description choline chloride 20.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

111 genes differentially expressed following the CRCGN013_HEPG2_24H:G02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 8.17443
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 6.94903
ATP11B ATPase, class VI, type 11B 6.45875
RPL39L ribosomal protein L39-like 4.6113
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 4.54746
PNKP polynucleotide kinase 3'-phosphatase 4.42178
MYLK myosin light chain kinase 4.41927
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 3.47305
LCN2 lipocalin 2 3.28889
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) 3.18717
ANO1 anoctamin 1, calcium activated chloride channel 3.18099
TESK1 testis-specific kinase 1 3.13044
TARBP2 TAR (HIV-1) RNA binding protein 2 3.1121
WASF3 WAS protein family, member 3 3.07323
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 3.00764
SFTPB surfactant protein B 2.83007
SEC13 SEC13 homolog (S. cerevisiae) 2.81615
NOSIP nitric oxide synthase interacting protein 2.73997
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.69859
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.68372
CASZ1 castor zinc finger 1 2.62143
PTOV1 prostate tumor overexpressed 1 2.59081
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.57515
OR10H1 olfactory receptor, family 10, subfamily H, member 1 2.56513
TMEM243 transmembrane protein 243, mitochondrial 2.53861
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.50473
SGF29 SAGA complex associated factor 29 2.49462
EPN2 epsin 2 2.48729
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.48269
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 2.48003
ETAA1 Ewing tumor-associated antigen 1 2.42022
RRAS related RAS viral (r-ras) oncogene homolog 2.37436
CRELD1 cysteine-rich with EGF-like domains 1 2.37068
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 2.34114
MCRS1 microspherule protein 1 2.33337
SCYL3 SCY1-like 3 (S. cerevisiae) 2.33047
CD79B CD79b molecule, immunoglobulin-associated beta 2.31429
RNF220 ring finger protein 220 2.30947
GSTO1 glutathione S-transferase omega 1 2.26653
POLL polymerase (DNA directed), lambda 2.25668
PYCR1 pyrroline-5-carboxylate reductase 1 2.24463
FAM114A1 family with sequence similarity 114, member A1 2.23497
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 2.226
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal 2.21263
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) 2.19785
MCM3 minichromosome maintenance complex component 3 2.17772
ANTKMT adenine nucleotide translocase lysine methyltransferase 2.17179
GTF2IRD1 GTF2I repeat domain containing 1 2.16154
CXCL2 chemokine (C-X-C motif) ligand 2 2.15382
CTSL cathepsin L 2.15163
PMF1-BGLAP PMF1-BGLAP readthrough 2.13877
TBCB tubulin folding cofactor B 2.1296
PEF1 penta-EF-hand domain containing 1 2.12445
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 2.12328
TMED1 transmembrane emp24 protein transport domain containing 1 2.09918
TBC1D19 TBC1 domain family, member 19 2.09314
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 2.0829
UBFD1 ubiquitin family domain containing 1 2.07598
PCBP3 poly(rC) binding protein 3 2.06478
VCP valosin containing protein 2.06433
PPP4C protein phosphatase 4, catalytic subunit 2.06186
FHL2 four and a half LIM domains 2 2.05892
LCMT1 leucine carboxyl methyltransferase 1 2.04921
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.0489
MRPS15 mitochondrial ribosomal protein S15 2.02077
MYBPC3 myosin binding protein C, cardiac 2.01569
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 2.00736
B3GAT1 beta-1,3-glucuronyltransferase 1 2.00438

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -8.06842
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -7.98854
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -7.23083
CCDC86 coiled-coil domain containing 86 -5.08411
SLC35F2 solute carrier family 35, member F2 -4.98451
CDC20 cell division cycle 20 -4.66021
NGRN neugrin, neurite outgrowth associated -4.31989
COG2 component of oligomeric golgi complex 2 -4.30703
FABP5 fatty acid binding protein 5 (psoriasis-associated) -4.04589
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.69513
HEATR1 HEAT repeat containing 1 -3.64585
CAB39 calcium binding protein 39 -3.64351
GDF15 growth differentiation factor 15 -3.56208
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.42589
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.30273
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.89999
ZNF586 zinc finger protein 586 -2.86608
FBXL12 F-box and leucine-rich repeat protein 12 -2.84778
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.73557
TM9SF3 transmembrane 9 superfamily member 3 -2.58716
FBXL6 F-box and leucine-rich repeat protein 6 -2.43544
RCOR3 REST corepressor 3 -2.41823
MIDEAS mitotic deacetylase associated SANT domain protein -2.32631
LAPTM4B lysosomal protein transmembrane 4 beta -2.23018
MED31 mediator complex subunit 31 -2.21863
RNF146 ring finger protein 146 -2.21156
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D -2.20528
SLC43A3 solute carrier family 43, member 3 -2.19553
FAM114A2 family with sequence similarity 114, member A2 -2.19291
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.19147
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa -2.15517
OXA1L oxidase (cytochrome c) assembly 1-like -2.14285
BAG2 BCL2-associated athanogene 2 -2.13309
RNF4 ring finger protein 4 -2.07466
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 -2.07384
DAAM2 dishevelled associated activator of morphogenesis 2 -2.06825
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.05942
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) -2.04591
PTPN7 protein tyrosine phosphatase, non-receptor type 7 -2.02582
CPB1 carboxypeptidase B1 (tissue) -2.01501
CHIC2 cysteine-rich hydrophobic domain 2 -2.00742
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase -2.00737
ANKRD10 ankyrin repeat domain 10 -2.00677