CRCGN013_HEPG2_24H:G08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sodium-nitrite 20.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

34 genes differentially expressed following the CRCGN013_HEPG2_24H:G08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.97942
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.36458
C2CD2 C2 calcium-dependent domain containing 2 4.25302
CHN1 chimerin 1 3.97194
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.84485
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.54108
LCN2 lipocalin 2 3.06761
GPATCH8 G patch domain containing 8 2.95216
VGLL4 vestigial-like family member 4 2.90302
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.39133
IGHMBP2 immunoglobulin mu binding protein 2 2.25195
USP18 ubiquitin specific peptidase 18 2.20271
FPGS folylpolyglutamate synthase 2.13454
KIF20A kinesin family member 20A 2.13441
TREM1 triggering receptor expressed on myeloid cells 1 2.11972

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -7.6344
ZDHHC6 zinc finger, DHHC-type containing 6 -4.31224
CCNB2 cyclin B2 -4.2273
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.02775
DSG2 desmoglein 2 -3.89016
NGRN neugrin, neurite outgrowth associated -3.82002
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.78743
LDHD lactate dehydrogenase D -3.75392
PCNA proliferating cell nuclear antigen -3.74462
ZNF586 zinc finger protein 586 -3.70904
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.49522
EGF epidermal growth factor -3.30375
GNAS GNAS complex locus -2.79347
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.74517
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.43562
TOR1A torsin family 1, member A (torsin A) -2.36649
SCCPDH saccharopine dehydrogenase (putative) -2.25655
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.23208
NEUROG1 neurogenin 1 -2.14912