CRCGN013_HEPG2_24H:G09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sodium-nitrite 10.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

51 genes differentially expressed following the CRCGN013_HEPG2_24H:G09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CBR3 carbonyl reductase 3 6.68975
CHMP6 charged multivesicular body protein 6 5.77169
STIMATE STIM activating enhancer 5.12101
GPATCH8 G patch domain containing 8 3.78714
PRR15L proline rich 15-like 3.77595
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.71524
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.63118
BLMH bleomycin hydrolase 3.60168
MAMLD1 mastermind-like domain containing 1 3.49077
NOTCH1 notch 1 3.45794
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.40686
UBQLN2 ubiquilin 2 3.34642
HLA-DMA major histocompatibility complex, class II, DM alpha 3.34457
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 3.33757
NOSIP nitric oxide synthase interacting protein 3.32228
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.26856
PPARG peroxisome proliferator-activated receptor gamma 3.23439
SQOR sulfide quinone oxidoreductase 3.16116
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 3.07508
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.94472
ADAT1 adenosine deaminase, tRNA-specific 1 2.76747
PRKCH protein kinase C, eta 2.51259
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.49215
IDE insulin-degrading enzyme 2.47907
SSBP2 single-stranded DNA binding protein 2 2.47574
RXYLT1 ribitol xylosyltransferase 1 2.35668
CDPF1 cysteine-rich, DPF motif domain containing 1 2.09889

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.62939
STK25 serine/threonine kinase 25 -3.78885
THAP11 THAP domain containing 11 -3.52706
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.04611
ITGB1BP1 integrin beta 1 binding protein 1 -2.92581
RPN1 ribophorin I -2.89908
OXA1L oxidase (cytochrome c) assembly 1-like -2.85996
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.72705
YME1L1 YME1-like 1 ATPase -2.63119
CTSD cathepsin D -2.51736
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.51179
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.47452
ZMIZ1 zinc finger, MIZ-type containing 1 -2.36941
MAPK13 mitogen-activated protein kinase 13 -2.36449
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.32377
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.32079
GNAS GNAS complex locus -2.31616
CCP110 centriolar coiled coil protein 110kDa -2.19741
EIF5 eukaryotic translation initiation factor 5 -2.19343
MYH9 myosin, heavy chain 9, non-muscle -2.18177
WASHC4 WASH complex subunit 4 -2.16774
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.16179
PCNA proliferating cell nuclear antigen -2.07507
PTPRK protein tyrosine phosphatase, receptor type, K -2.03169