CRCGN013_HEPG2_24H:G12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sodium-nitrite 1.28 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

64 genes differentially expressed following the CRCGN013_HEPG2_24H:G12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 6.35818
TATDN2 TatD DNase domain containing 2 5.04627
CAPN1 calpain 1, (mu/I) large subunit 4.54507
ABHD6 abhydrolase domain containing 6 3.49573
HLA-DMA major histocompatibility complex, class II, DM alpha 3.49095
PPARG peroxisome proliferator-activated receptor gamma 3.40573
ADAT1 adenosine deaminase, tRNA-specific 1 3.32799
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.24087
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 3.17402
EPHB2 EPH receptor B2 3.15594
BACE2 beta-site APP-cleaving enzyme 2 2.96568
MYLK myosin light chain kinase 2.94575
RRAGA Ras-related GTP binding A 2.88139
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.64741
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.60913
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.47617
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.45707
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.44294
SSBP2 single-stranded DNA binding protein 2 2.39514
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.32341
DYNLT3 dynein, light chain, Tctex-type 3 2.28441
VGLL4 vestigial-like family member 4 2.21878
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.20103
JADE2 jade family PHD finger 2 2.08501
ADAM10 ADAM metallopeptidase domain 10 2.00471

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.82496
GNAS GNAS complex locus -5.48944
FGFR4 fibroblast growth factor receptor 4 -4.976
KDM3A lysine (K)-specific demethylase 3A -4.19386
ELAC2 elaC ribonuclease Z 2 -4.13215
PCNA proliferating cell nuclear antigen -4.10796
LDHD lactate dehydrogenase D -3.90413
OXA1L oxidase (cytochrome c) assembly 1-like -3.39069
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.04805
ILK integrin-linked kinase -2.96475
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.84973
S100A4 S100 calcium binding protein A4 -2.6564
ZNF586 zinc finger protein 586 -2.58012
SLC35F2 solute carrier family 35, member F2 -2.54372
TLR4 toll-like receptor 4 -2.52989
RNF32 ring finger protein 32 -2.49573
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.46203
MAP7 microtubule-associated protein 7 -2.44015
IFT54 intraflagellar transport 54 -2.37464
CTNND1 catenin (cadherin-associated protein), delta 1 -2.25594
PRDM5 PR domain containing 5 -2.18488
ENTREP1 endosomal transmembrane epsin interactor 1 -2.17722
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.17297
TEX10 testis expressed 10 -2.1675
EMC10 ER membrane protein complex subunit 10 -2.15248
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 -2.12468
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.08738
LATS1 large tumor suppressor kinase 1 -2.08471
RAPSN receptor-associated protein of the synapse -2.06266
TBC1D22B TBC1 domain family, member 22B -2.05834
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 -2.05671
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.05582
BNC1 basonuclin 1 -2.0522
WDR7 WD repeat domain 7 -2.04843
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.02925
NRIP1 nuclear receptor interacting protein 1 -2.02721
HOXC13 homeobox C13 -2.01224
PSORS1C1 psoriasis susceptibility 1 candidate 1 -2.01186
ONECUT1 one cut homeobox 1 -2.00951