CRCGN013_HEPG2_24H:G17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description withaferin-a 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

221 genes differentially expressed following the CRCGN013_HEPG2_24H:G17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD4 abhydrolase domain containing 4 10.0
HMOX1 heme oxygenase 1 8.91804
CNPY3 canopy FGF signaling regulator 3 8.39258
TXNRD1 thioredoxin reductase 1 7.69512
TIMP2 TIMP metallopeptidase inhibitor 2 7.2486
MCOLN1 mucolipin 1 6.88191
LRP10 low density lipoprotein receptor-related protein 10 6.47301
CDPF1 cysteine-rich, DPF motif domain containing 1 6.40483
CBR1 carbonyl reductase 1 6.01917
SQSTM1 sequestosome 1 5.99799
H2BC12 H2B clustered histone 12 5.63192
CTSL cathepsin L 5.45646
FOSL1 FOS-like antigen 1 5.33925
KLHL21 kelch-like family member 21 5.12991
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 4.90275
LCN2 lipocalin 2 4.43849
ALAS1 5'-aminolevulinate synthase 1 4.39095
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 4.36259
UGDH UDP-glucose 6-dehydrogenase 4.23834
MVP major vault protein 4.2258
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 4.00095
CGRRF1 cell growth regulator with ring finger domain 1 3.95488
AMDHD2 amidohydrolase domain containing 2 3.84208
ANO10 anoctamin 10 3.78394
TMEM50A transmembrane protein 50A 3.78289
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 3.73282
KEAP1 kelch-like ECH-associated protein 1 3.66515
VAT1 vesicle amine transport 1 3.51125
ADI1 acireductone dioxygenase 1 3.48308
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 3.32787
ADGRE5 adhesion G protein-coupled receptor E5 3.27015
CHN1 chimerin 1 3.24099
BACE2 beta-site APP-cleaving enzyme 2 3.19915
NPC1 Niemann-Pick disease, type C1 3.17473
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 3.11489
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.09052
BCAP31 B-cell receptor-associated protein 31 3.07842
SNAP25 synaptosomal-associated protein, 25kDa 2.98622
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.9791
SYNE2 spectrin repeat containing, nuclear envelope 2 2.93555
GSTZ1 glutathione S-transferase zeta 1 2.92915
TXNL4B thioredoxin-like 4B 2.92397
RALB v-ral simian leukemia viral oncogene homolog B 2.86429
ECD ecdysoneless homolog (Drosophila) 2.81981
TATDN2 TatD DNase domain containing 2 2.8106
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 2.80106
RAB21 RAB21, member RAS oncogene family 2.78676
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.75259
FOXO4 forkhead box O4 2.6893
RNASE7 ribonuclease, RNase A family, 7 2.67851
TMEM109 transmembrane protein 109 2.64179
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 2.63197
PPARG peroxisome proliferator-activated receptor gamma 2.6028
BAG2 BCL2-associated athanogene 2 2.57075
MFSD1 major facilitator superfamily domain containing 1 2.55332
STXBP1 syntaxin binding protein 1 2.52719
MCUR1 mitochondrial calcium uniporter regulator 1 2.52603
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 2.45517
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.45326
ZMPSTE24 zinc metallopeptidase STE24 2.4476
GBA1 glucosylceramidase beta 1 2.44518
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.42501
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.40929
BLCAP bladder cancer associated protein 2.39783
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 2.38613
OSGIN1 oxidative stress induced growth inhibitor 1 2.37967
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein 2.37021
ELF4 E74-like factor 4 (ets domain transcription factor) 2.3656
FASTKD5 FAST kinase domains 5 2.36215
RAB5IF RAB5 interacting factor 2.32727
KDM3A lysine (K)-specific demethylase 3A 2.32006
RMC1 regulator of MON1-CCZ1 2.30811
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 2.30257
JUN jun proto-oncogene 2.26585
PGRMC1 progesterone receptor membrane component 1 2.26012
CTSA cathepsin A 2.25902
AURKA aurora kinase A 2.24042
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 2.23009
LOC124907782 dual specificity protein phosphatase 22 2.22317
BAG3 BCL2-associated athanogene 3 2.22307
NOSIP nitric oxide synthase interacting protein 2.21272
TBCC tubulin folding cofactor C 2.18527
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.17326
TDP2 tyrosyl-DNA phosphodiesterase 2 2.17079
RRAGA Ras-related GTP binding A 2.16829
DUSP3 dual specificity phosphatase 3 2.15762
GPC1 glypican 1 2.1351
PRR15L proline rich 15-like 2.1196
GHITM growth hormone inducible transmembrane protein 2.10425
NRBP1 nuclear receptor binding protein 1 2.0961
PELO pelota homolog (Drosophila) 2.09521
CARMIL1 capping protein regulator and myosin 1 linker 1 2.09245
GARRE1 granule associated Rac and RHOG effector 1 2.07628
COTL1 coactosin-like F-actin binding protein 1 2.06891
EMC3 ER membrane protein complex subunit 3 2.05957
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.04104
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.03677
BIRC2 baculoviral IAP repeat containing 2 2.03664
RRAGC Ras-related GTP binding C 2.01733
CDC25B cell division cycle 25B 2.00253
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.00223

decreased expression

Symbol Name Standardized Value
PCCB propionyl CoA carboxylase, beta polypeptide -10.0
COG2 component of oligomeric golgi complex 2 -9.29443
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -8.183
NISCH nischarin -7.05175
FGFR4 fibroblast growth factor receptor 4 -6.35454
TRAP1 TNF receptor-associated protein 1 -6.21202
ISOC1 isochorismatase domain containing 1 -5.54336
INTS3 integrator complex subunit 3 -5.2142
NUP85 nucleoporin 85kDa -4.65177
TOP2A topoisomerase (DNA) II alpha 170kDa -4.53243
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.50934
C2CD5 C2 calcium-dependent domain containing 5 -4.29131
PECR peroxisomal trans-2-enoyl-CoA reductase -4.26663
LDHD lactate dehydrogenase D -4.22113
B4GAT1 beta-1,4-glucuronyltransferase 1 -3.96979
TLCD3A TLC domain containing 3A -3.96597
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.95342
C5 complement component 5 -3.87178
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -3.75604
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.71281
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.70412
ETFB electron-transfer-flavoprotein, beta polypeptide -3.57019
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.36994
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -3.32951
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -3.326
HMGA2 high mobility group AT-hook 2 -3.3214
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -3.27321
CCP110 centriolar coiled coil protein 110kDa -3.24377
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.21282
OXA1L oxidase (cytochrome c) assembly 1-like -3.17368
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.17341
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.09857
HADH hydroxyacyl-CoA dehydrogenase -3.08271
MRPS7 mitochondrial ribosomal protein S7 -3.06625
CDK1 cyclin-dependent kinase 1 -3.06578
ENOPH1 enolase-phosphatase 1 -3.04352
LBR lamin B receptor -3.0348
TSPAN4 tetraspanin 4 -2.9623
PGM1 phosphoglucomutase 1 -2.95986
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -2.93116
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.90425
STMN1 stathmin 1 -2.83981
UBE3C ubiquitin protein ligase E3C -2.83508
PXMP2 peroxisomal membrane protein 2, 22kDa -2.8332
NT5DC2 5'-nucleotidase domain containing 2 -2.8006
NRIP1 nuclear receptor interacting protein 1 -2.78664
SUMO4 small ubiquitin-like modifier 4 -2.78506
NEK4 NIMA-related kinase 4 -2.78455
S100A4 S100 calcium binding protein A4 -2.73824
DUSP6 dual specificity phosphatase 6 -2.72744
TCL1B T-cell leukemia/lymphoma 1B -2.66512
PNKP polynucleotide kinase 3'-phosphatase -2.63972
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.62524
MRPL19 mitochondrial ribosomal protein L19 -2.60126
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.55354
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit -2.47924
PDHB pyruvate dehydrogenase (lipoamide) beta -2.46364
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.45444
DDB2 damage-specific DNA binding protein 2, 48kDa -2.43835
ZW10 zw10 kinetochore protein -2.4284
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.42623
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase -2.38
EDN1 endothelin 1 -2.37633
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -2.36997
SPDEF SAM pointed domain containing ETS transcription factor -2.35611
GET1 guided entry of tail-anchored proteins factor 1 -2.34207
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.3324
RAP1GAP2 RAP1 GTPase activating protein 2 -2.32797
IGF2 insulin-like growth factor 2 -2.32615
MRPL58 mitochondrial ribosomal protein L58 -2.30066
STK25 serine/threonine kinase 25 -2.29595
COG7 component of oligomeric golgi complex 7 -2.29408
CIRBP cold inducible RNA binding protein -2.28912
XYLT1 xylosyltransferase I -2.28495
ASGR1 asialoglycoprotein receptor 1 -2.26404
CCNA2 cyclin A2 -2.24092
SPTAN1 spectrin, alpha, non-erythrocytic 1 -2.21575
MTERF3 mitochondrial transcription termination factor 3 -2.19606
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 -2.15973
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.1574
MYB v-myb avian myeloblastosis viral oncogene homolog -2.15619
NOP53 NOP53 ribosome biogenesis factor -2.15222
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.15199
AKAP8 A kinase (PRKA) anchor protein 8 -2.14817
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -2.13897
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.1352
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.13397
PSRC1 proline/serine-rich coiled-coil 1 -2.13254
SGMS1 sphingomyelin synthase 1 -2.12479
ITGB1BP1 integrin beta 1 binding protein 1 -2.12395
LZTR1 leucine-zipper-like transcription regulator 1 -2.12083
CDK4 cyclin-dependent kinase 4 -2.11675
DOK7 docking protein 7 -2.11233
EGF epidermal growth factor -2.10875
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) -2.09945
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -2.09626
COL3A1 collagen, type III, alpha 1 -2.09241
TTYH1 tweety family member 1 -2.0902
CD300C CD300c molecule -2.07291
MAPK13 mitogen-activated protein kinase 13 -2.07133
PLS1 plastin 1 -2.07038
NRTN neurturin -2.07017
PYGL phosphorylase, glycogen, liver -2.06525
NNT nicotinamide nucleotide transhydrogenase -2.06379
DIXDC1 DIX domain containing 1 -2.06355
FOS FBJ murine osteosarcoma viral oncogene homolog -2.06104
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide -2.04838
ZNF692 zinc finger protein 692 -2.03979
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 -2.03923
UCKL1 uridine-cytidine kinase 1-like 1 -2.03253
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa -2.03061
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 -2.02786
FGL1 fibrinogen-like 1 -2.02028
ARMCX2 armadillo repeat containing, X-linked 2 -2.01996
DCN decorin -2.01893
DPH2 DPH2 homolog (S. cerevisiae) -2.01405
AHCY adenosylhomocysteinase -2.01312
GYG2 glycogenin 2 -2.00322
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.00127
PEG3 paternally expressed 3 -2.00117