CRCGN013_HEPG2_24H:G18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description withaferin-a 0.62 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

183 genes differentially expressed following the CRCGN013_HEPG2_24H:G18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD4 abhydrolase domain containing 4 8.39276
HMOX1 heme oxygenase 1 8.19533
TXNRD1 thioredoxin reductase 1 7.6437
LCN2 lipocalin 2 7.29148
CDPF1 cysteine-rich, DPF motif domain containing 1 6.88325
TIMP2 TIMP metallopeptidase inhibitor 2 6.27075
H2BC12 H2B clustered histone 12 5.57791
UGDH UDP-glucose 6-dehydrogenase 4.9141
FOSL1 FOS-like antigen 1 4.76876
CTSL cathepsin L 4.40143
SQSTM1 sequestosome 1 4.3095
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 4.25712
HLA-DMA major histocompatibility complex, class II, DM alpha 4.1409
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 4.06218
KEAP1 kelch-like ECH-associated protein 1 4.05886
KLHL21 kelch-like family member 21 3.88735
PARP2 poly (ADP-ribose) polymerase 2 3.81737
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.8026
CYCS cytochrome c, somatic 3.61809
TXNL4B thioredoxin-like 4B 3.60092
TBPL1 TBP-like 1 3.59412
TATDN2 TatD DNase domain containing 2 3.47604
ALAS1 5'-aminolevulinate synthase 1 3.46998
UBQLN2 ubiquilin 2 3.42448
CNPY3 canopy FGF signaling regulator 3 3.32157
STXBP1 syntaxin binding protein 1 3.3113
CDC45 cell division cycle 45 3.20797
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 3.20058
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.18952
MCOLN1 mucolipin 1 3.1702
CBR1 carbonyl reductase 1 3.09355
ANO10 anoctamin 10 2.98231
TMEM109 transmembrane protein 109 2.94269
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.88838
LRP10 low density lipoprotein receptor-related protein 10 2.83899
GALE UDP-galactose-4-epimerase 2.7172
FRS2 fibroblast growth factor receptor substrate 2 2.6755
PPARG peroxisome proliferator-activated receptor gamma 2.66739
MVP major vault protein 2.63504
HLA-DRA major histocompatibility complex, class II, DR alpha 2.63113
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.61366
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.60878
TUBB6 tubulin, beta 6 class V 2.5991
GATA2 GATA binding protein 2 2.52949
CCDC92 coiled-coil domain containing 92 2.4894
CDC20 cell division cycle 20 2.47251
BAG2 BCL2-associated athanogene 2 2.43615
BLCAP bladder cancer associated protein 2.40693
SSBP2 single-stranded DNA binding protein 2 2.38717
TRAK2 trafficking protein, kinesin binding 2 2.35989
CHMP1A charged multivesicular body protein 1A 2.35964
RRAGA Ras-related GTP binding A 2.32858
FASTKD5 FAST kinase domains 5 2.31539
GCLM glutamate-cysteine ligase, modifier subunit 2.29743
PPME1 protein phosphatase methylesterase 1 2.29603
LPAR2 lysophosphatidic acid receptor 2 2.28523
CDK5RAP2 CDK5 regulatory subunit associated protein 2 2.28129
TMEM50A transmembrane protein 50A 2.27619
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 2.26677
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 2.26239
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 2.21332
HOXA10 homeobox A10 2.2117
TERF2IP telomeric repeat binding factor 2, interacting protein 2.21137
CAB39 calcium binding protein 39 2.20384
BIRC2 baculoviral IAP repeat containing 2 2.17545
KDM3A lysine (K)-specific demethylase 3A 2.15835
BTK Bruton agammaglobulinemia tyrosine kinase 2.14716
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.13909
GSR glutathione reductase 2.12703
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 2.11739
SF3B4 splicing factor 3b, subunit 4, 49kDa 2.10961
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 2.10843
BAG3 BCL2-associated athanogene 3 2.1076
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 2.10632
ARL8B ADP-ribosylation factor-like 8B 2.09752
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 2.09525
PHGDH phosphoglycerate dehydrogenase 2.09039
REEP5 receptor accessory protein 5 2.07309
GPATCH8 G patch domain containing 8 2.0728
CREG1 cellular repressor of E1A-stimulated genes 1 2.06947
RMC1 regulator of MON1-CCZ1 2.06651
MMP1 matrix metallopeptidase 1 2.05042
GLIPR1 GLI pathogenesis-related 1 2.05025
CDCP1 CUB domain containing protein 1 2.03665
GNPDA1 glucosamine-6-phosphate deaminase 1 2.00315

decreased expression

Symbol Name Standardized Value
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -8.52171
PCCB propionyl CoA carboxylase, beta polypeptide -7.41215
C5 complement component 5 -6.88163
ISOC1 isochorismatase domain containing 1 -6.13937
C2CD5 C2 calcium-dependent domain containing 5 -6.02597
COG2 component of oligomeric golgi complex 2 -6.02548
FGFR4 fibroblast growth factor receptor 4 -5.94489
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.42985
GNAS GNAS complex locus -4.9616
MAPK13 mitogen-activated protein kinase 13 -4.5799
B4GAT1 beta-1,4-glucuronyltransferase 1 -4.20584
CHMP4B charged multivesicular body protein 4B -4.13837
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.05271
LDHD lactate dehydrogenase D -3.84136
INTS3 integrator complex subunit 3 -3.77363
TRAP1 TNF receptor-associated protein 1 -3.75207
PECR peroxisomal trans-2-enoyl-CoA reductase -3.73631
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.63999
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.57823
TRIB3 tribbles pseudokinase 3 -3.53765
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.53359
KLHDC2 kelch domain containing 2 -3.39316
PYGL phosphorylase, glycogen, liver -3.32257
ERBB2 erb-b2 receptor tyrosine kinase 2 -3.29037
PCNA proliferating cell nuclear antigen -3.20335
ETFB electron-transfer-flavoprotein, beta polypeptide -3.19316
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -3.07831
BZW2 basic leucine zipper and W2 domains 2 -2.98948
PGM1 phosphoglucomutase 1 -2.93035
AKAP8 A kinase (PRKA) anchor protein 8 -2.89398
STAP2 signal transducing adaptor family member 2 -2.83408
TOP2A topoisomerase (DNA) II alpha 170kDa -2.83257
HADH hydroxyacyl-CoA dehydrogenase -2.68786
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -2.67997
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.6548
ZNF586 zinc finger protein 586 -2.65386
ERBB3 erb-b2 receptor tyrosine kinase 3 -2.64613
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.62925
ZNF274 zinc finger protein 274 -2.49155
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 -2.47588
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.47285
APOM apolipoprotein M -2.45654
NIT1 nitrilase 1 -2.45271
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.40617
FBXL12 F-box and leucine-rich repeat protein 12 -2.3981
NISCH nischarin -2.35396
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like -2.35284
NRIP1 nuclear receptor interacting protein 1 -2.35175
ITGA7 integrin, alpha 7 -2.34425
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.34134
PHKA2 phosphorylase kinase, alpha 2 (liver) -2.3334
AHCY adenosylhomocysteinase -2.33094
AOC3 amine oxidase, copper containing 3 -2.3262
TGIF2 TGFB-induced factor homeobox 2 -2.31942
RPL10A ribosomal protein L10a -2.30672
E2F5 E2F transcription factor 5, p130-binding -2.30159
SGPP2 sphingosine-1-phosphate phosphatase 2 -2.29945
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5 -2.28285
NHP2 NHP2 ribonucleoprotein -2.27951
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.27678
GSPT2 G1 to S phase transition 2 -2.2706
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.25816
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 -2.21701
TGDS TDP-glucose 4,6-dehydratase -2.20006
DDB2 damage-specific DNA binding protein 2, 48kDa -2.16683
SHPK sedoheptulokinase -2.15873
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) -2.15384
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 -2.14934
ZNF512B zinc finger protein 512B -2.14607
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 -2.14385
DCK deoxycytidine kinase -2.14072
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.13856
ZNF606 zinc finger protein 606 -2.13657
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) -2.1334
ZNF721 zinc finger protein 721 -2.13033
EFR3B EFR3 homolog B (S. cerevisiae) -2.12269
ZNF492 zinc finger protein 492 -2.12211
PROZ protein Z, vitamin K-dependent plasma glycoprotein -2.11524
HMOX2 heme oxygenase 2 -2.11071
ITGB1BP1 integrin beta 1 binding protein 1 -2.09573
FANCF Fanconi anemia, complementation group F -2.08841
PLA2G3 phospholipase A2, group III -2.08189
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 -2.0661
NXPH3 neurexophilin 3 -2.06564
TM7SF3 transmembrane 7 superfamily member 3 -2.06019
TM7SF2 transmembrane 7 superfamily member 2 -2.05967
ZNF253 zinc finger protein 253 -2.05501
GCDH glutaryl-CoA dehydrogenase -2.05233
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4 -2.05085
OR7C2 olfactory receptor, family 7, subfamily C, member 2 -2.0446
MEOX1 mesenchyme homeobox 1 -2.03234
TCL1B T-cell leukemia/lymphoma 1B -2.03176
TCEAL4 transcription elongation factor A (SII)-like 4 -2.02379
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) -2.01768
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.01355
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -2.0087
ASMT acetylserotonin O-methyltransferase -2.00658
SNX11 sorting nexin 11 -2.00185