CRCGN013_HEPG2_24H:G19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description piperonyl-butoxide 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

52 genes differentially expressed following the CRCGN013_HEPG2_24H:G19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 6.73446
CDC45 cell division cycle 45 4.37449
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.04711
ADGRE5 adhesion G protein-coupled receptor E5 4.00942
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.99065
PNKP polynucleotide kinase 3'-phosphatase 3.87566
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.63147
RPP38 ribonuclease P/MRP 38kDa subunit 3.58016
UBQLN2 ubiquilin 2 3.17155
EPHA3 EPH receptor A3 3.06979
SCRN1 secernin 1 3.00189
LOC122526780 uncharacterized LOC122526780 2.71559
PEX11A peroxisomal biogenesis factor 11 alpha 2.54345
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.44948
TBP TATA box binding protein 2.33778
SSBP2 single-stranded DNA binding protein 2 2.32679
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.32228
SQSTM1 sequestosome 1 2.18218
PRKCH protein kinase C, eta 2.14635
PCP4 Purkinje cell protein 4 2.10081
ABHD4 abhydrolase domain containing 4 2.05448
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.03655

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -5.47139
OXA1L oxidase (cytochrome c) assembly 1-like -5.4613
KDM3A lysine (K)-specific demethylase 3A -3.75082
MRPS2 mitochondrial ribosomal protein S2 -3.69128
ADI1 acireductone dioxygenase 1 -3.63694
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.57358
DNM1L dynamin 1-like -3.53003
CCNB1 cyclin B1 -3.47177
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.28638
CDC20 cell division cycle 20 -2.97942
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.77975
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.63904
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.6105
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.45465
PDHX pyruvate dehydrogenase complex, component X -2.44096
UGDH UDP-glucose 6-dehydrogenase -2.41716
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) -2.35004
CCNB2 cyclin B2 -2.32794
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.2857
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.26931
TLCD3A TLC domain containing 3A -2.24995
FASTKD5 FAST kinase domains 5 -2.22838
STMN1 stathmin 1 -2.22348
AURKB aurora kinase B -2.21521
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.19649
COMMD9 COMM domain containing 9 -2.17897
ZNF586 zinc finger protein 586 -2.1577
COG4 component of oligomeric golgi complex 4 -2.07333
RRM1 ribonucleotide reductase M1 -2.03109
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.02728