CRCGN013_HEPG2_24H:G23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description piperonyl-butoxide 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

37 genes differentially expressed following the CRCGN013_HEPG2_24H:G23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHN1 chimerin 1 5.84004
MYLK myosin light chain kinase 5.1097
PPARG peroxisome proliferator-activated receptor gamma 4.8189
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.4021
NOSIP nitric oxide synthase interacting protein 3.91478
KLHL21 kelch-like family member 21 3.77617
STAP2 signal transducing adaptor family member 2 3.27803
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.93318
SFTPB surfactant protein B 2.85676
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.532
RSU1 Ras suppressor protein 1 2.44295
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.41135
CD40 CD40 molecule, TNF receptor superfamily member 5 2.16146
CRYBG1 crystallin beta-gamma domain containing 1 2.13623
KIFBP kinesin family binding protein 2.02791

decreased expression

Symbol Name Standardized Value
TARBP1 TAR (HIV-1) RNA binding protein 1 -8.12353
PCNA proliferating cell nuclear antigen -6.23734
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.93227
CD320 CD320 molecule -4.63453
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.06686
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.0023
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.95863
MTA1 metastasis associated 1 -3.92586
OXA1L oxidase (cytochrome c) assembly 1-like -3.89471
FGFR4 fibroblast growth factor receptor 4 -3.77986
GOLT1B golgi transport 1B -3.23482
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.95689
TLR4 toll-like receptor 4 -2.85919
STAT1 signal transducer and activator of transcription 1, 91kDa -2.75983
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.7592
EXT1 exostosin glycosyltransferase 1 -2.75736
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.68563
RNF167 ring finger protein 167 -2.4588
GTPBP8 GTP-binding protein 8 (putative) -2.39073
LOC124907782 dual specificity protein phosphatase 22 -2.15734
SLC35F2 solute carrier family 35, member F2 -2.08129
NRIP1 nuclear receptor interacting protein 1 -2.04823