CRCGN013_HEPG2_24H:H01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methacrylonitrile 41.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

227 genes differentially expressed following the CRCGN013_HEPG2_24H:H01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SSBP2 single-stranded DNA binding protein 2 6.50472
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.43871
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.40662
TREM1 triggering receptor expressed on myeloid cells 1 6.26479
E2F2 E2F transcription factor 2 6.25855
SNAP25 synaptosomal-associated protein, 25kDa 5.22295
AMDHD2 amidohydrolase domain containing 2 5.15775
HLA-DMA major histocompatibility complex, class II, DM alpha 5.12268
CBR3 carbonyl reductase 3 5.04457
CXCL2 chemokine (C-X-C motif) ligand 2 4.91565
LAGE3 L antigen family, member 3 4.56826
GPER1 G protein-coupled estrogen receptor 1 4.41068
BPHL biphenyl hydrolase-like (serine hydrolase) 3.59258
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.53846
HLA-DRA major histocompatibility complex, class II, DR alpha 3.39014
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.19653
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.10017
F2RL2 coagulation factor II (thrombin) receptor-like 2 3.08043
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.07747
PRKCD protein kinase C, delta 3.057
CASS4 Cas scaffolding protein family member 4 2.9197
BACE2 beta-site APP-cleaving enzyme 2 2.83174
LSAMP limbic system-associated membrane protein 2.82756
RRAGA Ras-related GTP binding A 2.78168
BPY2B basic charge, Y-linked, 2B 2.63011
OR3A2 olfactory receptor, family 3, subfamily A, member 2 2.61172
ZNF334 zinc finger protein 334 2.58937
DMTF1 cyclin D binding myb-like transcription factor 1 2.58548
TEX12 testis expressed 12 2.58158
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 2.5759
EPHA5 EPH receptor A5 2.57058
LUZP2 leucine zipper protein 2 2.52221
ZNF132 zinc finger protein 132 2.51838
SCN9A sodium channel, voltage gated, type IX alpha subunit 2.51024
CFAP46 cilia and flagella associated protein 46 2.48918
CNTNAP3B contactin associated protein-like 3B 2.48611
SPATA31A3 SPATA31 subfamily A, member 3 2.48035
DNALI1 dynein, axonemal, light intermediate chain 1 2.46687
ZNF471 zinc finger protein 471 2.46263
ANO1 anoctamin 1, calcium activated chloride channel 2.45768
KRT8 keratin 8, type II 2.45676
MSH4 mutS homolog 4 2.45603
BFSP2 beaded filament structural protein 2, phakinin 2.44726
MEGF8 multiple EGF-like-domains 8 2.44455
SCN7A sodium channel, voltage gated, type VII alpha subunit 2.43408
OR10H2 olfactory receptor, family 10, subfamily H, member 2 2.42579
USP53 ubiquitin specific peptidase 53 2.42544
ZNF749 zinc finger protein 749 2.41547
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 2.41504
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.38607
PPP1R3A protein phosphatase 1, regulatory subunit 3A 2.38099
KIRREL1 kirre like nephrin family adhesion molecule 1 2.35592
ZFP2 ZFP2 zinc finger protein 2.3522
MAGEB3 melanoma antigen family B3 2.34243
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 2.34207
CCNA1 cyclin A1 2.32973
ELOA2 elongin A2 2.32677
PBOV1 prostate and breast cancer overexpressed 1 2.32187
IMPG1 interphotoreceptor matrix proteoglycan 1 2.3187
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.31675
OR1D4 olfactory receptor, family 1, subfamily D, member 4 (gene/pseudogene) 2.31365
GLRA1 glycine receptor, alpha 1 2.30805
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 2.30296
ATXN3L ataxin 3-like 2.30186
IFT54 intraflagellar transport 54 2.30141
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 2.30074
PHAF1 phagosome assembly factor 1 2.29587
FPGT-TNNI3K FPGT-TNNI3K readthrough 2.29508
ELAC1 elaC ribonuclease Z 1 2.29386
GRIA1 glutamate receptor, ionotropic, AMPA 1 2.28897
RFX3 regulatory factor X, 3 (influences HLA class II expression) 2.28466
HNRNPCL1 heterogeneous nuclear ribonucleoprotein C-like 1 2.282
PLSCR2 phospholipid scramblase 2 2.27739
NCAM2 neural cell adhesion molecule 2 2.27452
GP6 glycoprotein VI (platelet) 2.27172
LMO7 LIM domain 7 2.2652
MLNR motilin receptor 2.26445
TRPC3 transient receptor potential cation channel, subfamily C, member 3 2.2455
USP27X ubiquitin specific peptidase 27, X-linked 2.24173
PPIAL4H peptidylprolyl isomerase A like 4H 2.23904
PDE12 phosphodiesterase 12 2.23777
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 2.23648
ZNF589 zinc finger protein 589 2.23585
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.23414
TLL2 tolloid-like 2 2.23128
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 2.2288
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 2.22648
GRM7 glutamate receptor, metabotropic 7 2.22576
PHF14 PHD finger protein 14 2.22146
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.21767
TEX28 testis expressed 28 2.21521
FGF22 fibroblast growth factor 22 2.21243
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 2.20609
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.20398
GTPBP10 GTP-binding protein 10 (putative) 2.19932
EFNA2 ephrin-A2 2.19895
DUSP21 dual specificity phosphatase 21 2.19846
MYEF2 myelin expression factor 2 2.19558
HCRTR1 hypocretin (orexin) receptor 1 2.19548
CFAP43 cilia and flagella associated protein 43 2.1921
RCVRN recoverin 2.19153
CMA1 chymase 1, mast cell 2.19137
PAPOLB poly(A) polymerase beta (testis specific) 2.18998
DRD3 dopamine receptor D3 2.18764
ZNF407 zinc finger protein 407 2.18631
MMP25 matrix metallopeptidase 25 2.18042
HOXD12 homeobox D12 2.17807
ZFY zinc finger protein, Y-linked 2.17771
ADRB1 adrenoceptor beta 1 2.16806
IFNA8 interferon, alpha 8 2.1625
MTNR1A melatonin receptor 1A 2.16216
SOX14 SRY (sex determining region Y)-box 14 2.162
POU6F2 POU class 6 homeobox 2 2.15944
SCRT1 scratch family zinc finger 1 2.15446
TREH trehalase (brush-border membrane glycoprotein) 2.15212
LRP10 low density lipoprotein receptor-related protein 10 2.15182
ANK1 ankyrin 1, erythrocytic 2.15119
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.14893
JHY junctional cadherin complex regulator 2.14781
ZNF81 zinc finger protein 81 2.14328
POU4F3 POU class 4 homeobox 3 2.14305
CRYBA1 crystallin, beta A1 2.14037
ZNF440 zinc finger protein 440 2.13948
ADCY10 adenylate cyclase 10 (soluble) 2.1393
HID1 HID1 domain containing 2.13898
BRINP1 bone morphogenetic protein/retinoic acid inducible neural-specific 1 2.13883
MTSS2 MTSS I-BAR domain containing 2 2.13875
SSTR1 somatostatin receptor 1 2.13715
PTTG2 pituitary tumor-transforming 2 2.13649
ASCL2 achaete-scute family bHLH transcription factor 2 2.13055
RFPL1 ret finger protein-like 1 2.13047
ZNF780B zinc finger protein 780B 2.12885
SOX5 SRY (sex determining region Y)-box 5 2.1282
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 2.12587
PF4V1 platelet factor 4 variant 1 2.12512
NPVF neuropeptide VF precursor 2.1234
TMEM19 transmembrane protein 19 2.12334
CCDC33 coiled-coil domain containing 33 2.12152
GNG13 guanine nucleotide binding protein (G protein), gamma 13 2.12078
TRIM49B tripartite motif containing 49B 2.11871
LBX1 ladybird homeobox 1 2.11865
ATP1B4 ATPase, Na+/K+ transporting, beta 4 polypeptide 2.117
ANKRD34C ankyrin repeat domain 34C 2.11418
ZNF492 zinc finger protein 492 2.11286
ADAM2 ADAM metallopeptidase domain 2 2.1128
ZNF318 zinc finger protein 318 2.11048
CFAP68 cilia and flagella associated protein 68 2.10619
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 2.10564
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 2.10467
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 2.10429
IRS4 insulin receptor substrate 4 2.10152
CNPY3 canopy FGF signaling regulator 3 2.1015
TAL1 T-cell acute lymphocytic leukemia 1 2.09805
OR3A1 olfactory receptor, family 3, subfamily A, member 1 2.09799
ASTN1 astrotactin 1 2.09729
SLC30A4 solute carrier family 30 (zinc transporter), member 4 2.09438
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.09429
TMC7 transmembrane channel-like 7 2.09358
AICDA activation-induced cytidine deaminase 2.08934
GP5 glycoprotein V (platelet) 2.08843
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 2.08106
FSHR follicle stimulating hormone receptor 2.081
ZNF214 zinc finger protein 214 2.08045
SLC25A30 solute carrier family 25, member 30 2.07946
MROH9 maestro heat-like repeat family member 9 2.07295
MAGEB1 melanoma antigen family B1 2.0723
FAM135A family with sequence similarity 135, member A 2.07048
GPR75 G protein-coupled receptor 75 2.0694
FGF8 fibroblast growth factor 8 (androgen-induced) 2.06468
GRID2 glutamate receptor, ionotropic, delta 2 2.06276
MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2.06219
GSC2 goosecoid homeobox 2 2.05956
ADGB androglobin 2.05803
CYSLTR1 cysteinyl leukotriene receptor 1 2.05392
CCDC144A coiled-coil domain containing 144A 2.05312
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit 2.04935
PSG3 pregnancy specific beta-1-glycoprotein 3 2.0471
C5AR2 complement component 5a receptor 2 2.04675
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.04338
OR2F2 olfactory receptor, family 2, subfamily F, member 2 2.04314
ADGRL3 adhesion G protein-coupled receptor L3 2.04072
NOX3 NADPH oxidase 3 2.04027
TRPC5 transient receptor potential cation channel, subfamily C, member 5 2.03982
AMELX amelogenin, X-linked 2.03931
KRTAP9-9 keratin associated protein 9-9 2.03892
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 2.02869
MTMR7 myotubularin related protein 7 2.0285
GCM2 glial cells missing homolog 2 (Drosophila) 2.02675
IRGC immunity-related GTPase family, cinema 2.0263
CDY1 chromodomain protein, Y-linked, 1 2.02508
PRDM9 PR domain containing 9 2.02494
KDM4D lysine (K)-specific demethylase 4D 2.02319
CDH20 cadherin 20, type 2 2.02316
MAP3K7CL MAP3K7 C-terminal like 2.02128
JPH3 junctophilin 3 2.02088
IFNA6 interferon, alpha 6 2.01939
OTUD7B OTU deubiquitinase 7B 2.01878
H2BC15 H2B clustered histone 15 2.01666
FOXD3 forkhead box D3 2.01144
SNTG2 syntrophin, gamma 2 2.01054
TAS2R8 taste receptor, type 2, member 8 2.01004
MC5R melanocortin 5 receptor 2.00999
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase 2.00997
LIPF lipase, gastric 2.00929
ASIC2 acid sensing (proton gated) ion channel 2 2.00569
NEUROG2 neurogenin 2 2.00146
PITPNM3 PITPNM family member 3 2.00058

decreased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 -5.26648
NT5DC2 5'-nucleotidase domain containing 2 -4.76189
LDHD lactate dehydrogenase D -4.59774
C5 complement component 5 -3.63814
RNF167 ring finger protein 167 -3.3938
FBXL12 F-box and leucine-rich repeat protein 12 -3.2146
TXNDC9 thioredoxin domain containing 9 -3.20878
NGRN neugrin, neurite outgrowth associated -2.88256
OXA1L oxidase (cytochrome c) assembly 1-like -2.86457
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.69621
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.61127
SNX11 sorting nexin 11 -2.57951
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.49878
AKAP8 A kinase (PRKA) anchor protein 8 -2.46567
CCNB2 cyclin B2 -2.41847
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.32352
IER3 immediate early response 3 -2.29503
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.28976
ABHD10 abhydrolase domain containing 10 -2.15092
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.0147