CRCGN013_HEPG2_24H:H03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methacrylonitrile 10.45 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

33 genes differentially expressed following the CRCGN013_HEPG2_24H:H03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 8.81536
PPARG peroxisome proliferator-activated receptor gamma 5.18276
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.36672
CHN1 chimerin 1 4.00738
DIPK1A divergent protein kinase domain 1A 3.06501
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.91121
LOC122526780 uncharacterized LOC122526780 2.7266
SSBP2 single-stranded DNA binding protein 2 2.67622
KLHL9 kelch-like family member 9 2.36067
EGF epidermal growth factor 2.20671
TOPBP1 topoisomerase (DNA) II binding protein 1 2.04411
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.01639

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.61268
LAP3 leucine aminopeptidase 3 -4.67938
VAT1 vesicle amine transport 1 -4.65714
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -4.54774
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.41152
ADI1 acireductone dioxygenase 1 -4.28764
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.05264
TRAP1 TNF receptor-associated protein 1 -3.96085
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.77826
GNAS GNAS complex locus -3.02099
CD58 CD58 molecule -2.69963
NRIP1 nuclear receptor interacting protein 1 -2.66657
TLR4 toll-like receptor 4 -2.52438
OXA1L oxidase (cytochrome c) assembly 1-like -2.38091
SNX11 sorting nexin 11 -2.29199
TEX10 testis expressed 10 -2.22263
CCNB1 cyclin B1 -2.21274
TCERG1 transcription elongation regulator 1 -2.17867
TRIM25 tripartite motif containing 25 -2.13303
TUT7 terminal uridylyl transferase 7 -2.06056
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.05602